Phosphoglycerate kinase 1 (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2)
1_MSLSN 6_ KLTLD 11_ KLDVK 16_ GKRVV 21_ MRVDF 26_ NVPMK 31_ NNQIT 36_ NNQRI 41_ KAAVP 46_ SIKFC 51_ LDNGA 56_ KSVVL 61_ MSHLG 66_ RPDGV 71_ PMPDK 76_ YSLEP 81_ VAVEL 86_ KSLLG 91_ KDVLF 96_ LKDCV 101_ GPEVE 106_ KACAN 111_ PAAGS 116_ VILLE 121_ NLRFH 126_ VEEEG 131_ KGKDA 136_ SGNKV 141_ KAEPA 146_ KIEAF 151_ RASLS 156_ KLGDV 161_ YVNDA 166_ FGTAH 171_ RAHSS 176_ MVGVN 181_ LPQKA 186_ GGFLM 191_ KKELN 196_ YFAKA 201_ LESPE 206_ RPFLA 211_ ILGGA 216_ KVADK 221_ IQLIN 226_ NMLDK 231_ VNEMI 236_ IGGGM 241_ AFTFL 246_ KVLNN 251_ MEIGT 256_ SLFDE 261_ EGAKI 266_ VKDLM 271_ SKAEK 276_ NGVKI 281_ TLPVD 286_ FVTAD 291_ KFDEN 296_ AKTGQ 301_ ATVAS 306_ GIPAG 311_ WMGLD 316_ CGPES 321_ SKKYA 326_ EAVTR 331_ AKQIV 336_ WNGPV 341_ GVFEW 346_ EAFAR 351_ GTKAL 356_ MDEVV 361_ KATSR 366_ GCITI 371_ IGGGD 376_ TATCC 381_ AKWNT 386_ EDKVS 391_ HVSTG 396_ GGASL 401_ ELLEG 406_ KVLPG 411_VDALS
1: Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines (PubMed:18463139). In addition to its role as a glycolytic enzyme, it seems that PGK1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl-coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis (PubMed:26942675, PubMed:36849569). May play a role in sperm motility (PubMed:26677959)