Adenylate kinase isoenzyme 1 (AK 1) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 1) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) (Myokinase)
1_MEEKL 6_ KKTKI 11_ IFVVG 16_ GPGSG 21_ KGTQC 26_ EKIVQ 31_ KYGYT 36_ HLSTG 41_ DLLRS 46_ EVSSG 51_ SARGK 56_ KLSEI 61_ MEKGQ 66_ LVPLE 71_ TVLDM 76_ LRDAM 81_ VAKVN 86_ TSKGF 91_ LIDGY 96_ PREVQ 101_ QGEEF 106_ ERRIG 111_ QPTLL 116_ LYVDA 121_ GPETM 126_ TQRLL 131_ KRGET 136_ SGRVD 141_ DNEET 146_ IKKRL 151_ ETYYK 156_ ATEPV 161_ IAFYE 166_ KRGIV 171_ RKVNA 176_ EGSVD 181_ SVFSQ 186_VCTHL
1: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) (PubMed:21080915, PubMed:23416111, PubMed:2542324). Also catalyzes at a very low rate the synthesis of thiamine triphosphate (ThTP) from thiamine diphosphate (ThDP) and ADP (By similarity)