Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]
1_MAHVR 6_ GLQLP 11_ GCLAL 16_ AALCS 21_ LVHSQ 26_ HVFLA 31_ PQQAR 36_ SLLQR 41_ VRRAN 46_ TFLEE 51_ VRKGN 56_ LEREC 61_ VEETC 66_ SYEEA 71_ FEALE 76_ SSTAT 81_ DVFWA 86_ KYTAC 91_ ETART 96_ PRDKL 101_ AACLE 106_ GNCAE 111_ GLGTN 116_ YRGHV 121_ NITRS 126_ GIECQ 131_ LWRSR 136_ YPHKP 141_ EINST 146_ THPGA 151_ DLQEN 156_ FCRNP 161_ DSSTT 166_ GPWCY 171_ TTDPT 176_ VRRQE 181_ CSIPV 186_ CGQDQ 191_ VTVAM 196_ TPRSE 201_ GSSVN 206_ LSPPL 211_ EQCVP 216_ DRGQQ 221_ YQGRL 226_ AVTTH 231_ GLPCL 236_ AWASA 241_ QAKAL 246_ SKHQD 251_ FNSAV 256_ QLVEN 261_ FCRNP 266_ DGDEE 271_ GVWCY 276_ VAGKP 281_ GDFGY 286_ CDLNY 291_ CEEAV 296_ EEETG 301_ DGLDE 306_ DSDRA 311_ IEGRT 316_ ATSEY 321_ QTFFN 326_ PRTFG 331_ SGEAD 336_ CGLRP 341_ LFEKK 346_ SLEDK 351_ TEREL 356_ LESYI 361_ DGRIV 366_ EGSDA 371_ EIGMS 376_ PWQVM 381_ LFRKS 386_ PQELL 391_ CGASL 396_ ISDRW 401_ VLTAA 406_ HCLLY 411_ PPWDK 416_ NFTEN 421_ DLLVR 426_ IGKHS 431_ RTRYE 436_ RNIEK 441_ ISMLE 446_ KIYIH 451_ PRYNW 456_ RENLD 461_ RDIAL 466_ MKLKK 471_ PVAFS 476_ DYIHP 481_ VCLPD 486_ RETAA 491_ SLLQA 496_ GYKGR 501_ VTGWG 506_ NLKET 511_ WTANV 516_ GKGQP 521_ SVLQV 526_ VNLPI 531_ VERPV 536_ CKDST 541_ RIRIT 546_ DNMFC 551_ AGYKP 556_ DEGKR 561_ GDACE 566_ GDSGG 571_ PFVMK 576_ SPFNN 581_ RWYQM 586_ GIVSW 591_ GEGCD 596_ RDGKY 601_ GFYTH 606_ VFRLK 611_ KWIQK 616_VIDQF
1: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Activates coagulation factor XI (F11); activation is promoted by the contact with negatively charged surfaces (PubMed:2019570, PubMed:21976677). Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells (PubMed:30568593, PubMed:9780208)