Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
1_MGRPL 6_ HLVLL 11_ SASLA 16_ GLLLL 21_ GESLF 26_ IRREQ 31_ ANNIL 36_ ARVTR 41_ ANSFL 46_ EEMKK 51_ GHLER 56_ ECMEE 61_ TCSYE 66_ EAREV 71_ FEDSD 76_ KTNEF 81_ WNKYK 86_ DGDQC 91_ ETSPC 96_ QNQGK 101_ CKDGL 106_ GEYTC 111_ TCLEG 116_ FEGKN 121_ CELFT 126_ RKLCS 131_ LDNGD 136_ CDQFC 141_ HEEQN 146_ SVVCS 151_ CARGY 156_ TLADN 161_ GKACI 166_ PTGPY 171_ PCGKQ 176_ TLERR 181_ KRSVA 186_ QATSS 191_ SGEAP 196_ DSITW 201_ KPYDA 206_ ADLDP 211_ TENPF 216_ DLLDF 221_ NQTQP 226_ ERGDN 231_ NLTRI 236_ VGGQE 241_ CKDGE 246_ CPWQA 251_ LLINE 256_ ENEGF 261_ CGGTI 266_ LSEFY 271_ ILTAA 276_ HCLYQ 281_ AKRFK 286_ VRVGD 291_ RNTEQ 296_ EEGGE 301_ AVHEV 306_ EVVIK 311_ HNRFT 316_ KETYD 321_ FDIAV 326_ LRLKT 331_ PITFR 336_ MNVAP 341_ ACLPE 346_ RDWAE 351_ STLMT 356_ QKTGI 361_ VSGFG 366_ RTHEK 371_ GRQST 376_ RLKML 381_ EVPYV 386_ DRNSC 391_ KLSSS 396_ FIITQ 401_ NMFCA 406_ GYDTK 411_ QEDAC 416_ QGDSG 421_ GPHVT 426_ RFKDT 431_ YFVTG 436_ IVSWG 441_ EGCAR 446_ KGKYG 451_ IYTKV 456_ TAFLK 461_ WIDRS 466_ MKTRG 471_ LPKAK 476_ SHAPE 481_VITSS
1: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting (PubMed:22409427). Factor Xa activates pro-inflammatory signaling pathways in a protease-activated receptor (PAR)-dependent manner (PubMed:24041930, PubMed:30568593, PubMed:34831181, PubMed:18202198). Up-regulates expression of protease-activated receptors (PARs) F2R, F2RL1 and F2RL2 in dermal microvascular endothelial cells (PubMed:35738824). Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL6, in cardiac fibroblasts and umbilical vein endothelial cells in PAR-1/F2R-dependent manner (PubMed:30568593, PubMed:34831181). Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2, IL6, TNF-alpha/TNF, IL-1beta/IL1B, IL8/CXCL8 and IL18, in endothelial cells and atrial tissues (PubMed:24041930, PubMed:35738824, PubMed:9780208). Induces expression of adhesion molecules, such as ICAM1, VCAM1 and SELE, in endothelial cells and atrial tissues (PubMed:24041930, PubMed:35738824, PubMed:9780208). Increases expression of phosphorylated ERK1/2 in dermal microvascular endothelial cells and atrial tissues (PubMed:24041930, PubMed:35738824). Triggers activation of the transcription factor NF-kappa-B in dermal microvascular endothelial cells and atrial tissues (PubMed:24041930, PubMed:35738824). Activates pro-inflammatory and pro-fibrotic responses in dermal fibroblasts and enhances wound healing probably via PAR-2/F2RL1-dependent mechanism (PubMed:18202198). Activates barrier protective signaling responses in endothelial cells in PAR-2/F2RL1-dependent manner; the activity depends on the cleavage of PAR-2/F2RL1 by factor Xa (PubMed:22409427). Up-regulates expression of plasminogen activator inhibitor 1 (SERPINE1) in atrial tissues (PubMed:24041930)