Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]
1_MEHKE 6_ VVLLL 11_ LLFLK 16_ SGQGE 21_ PLDDY 26_ VNTQG 31_ ASLFS 36_ VTKKQ 41_ LGAGS 46_ IEECA 51_ AKCEE 56_ DEEFT 61_ CRAFQ 66_ YHSKE 71_ QQCVI 76_ MAENR 81_ KSSII 86_ IRMRD 91_ VVLFE 96_ KKVYL 101_ SECKT 106_ GNGKN 111_ YRGTM 116_ SKTKN 121_ GITCQ 126_ KWSST 131_ SPHRP 136_ RFSPA 141_ THPSE 146_ GLEEN 151_ YCRNP 156_ DNDPQ 161_ GPWCY 166_ TTDPE 171_ KRYDY 176_ CDILE 181_ CEEEC 186_ MHCSG 191_ ENYDG 196_ KISKT 201_ MSGLE 206_ CQAWD 211_ SQSPH 216_ AHGYI 221_ PSKFP 226_ NKNLK 231_ KNYCR 236_ NPDRE 241_ LRPWC 246_ FTTDP 251_ NKRWE 256_ LCDIP 261_ RCTTP 266_ PPSSG 271_ PTYQC 276_ LKGTG 281_ ENYRG 286_ NVAVT 291_ VSGHT 296_ CQHWS 301_ AQTPH 306_ THNRT 311_ PENFP 316_ CKNLD 321_ ENYCR 326_ NPDGK 331_ RAPWC 336_ HTTNS 341_ QVRWE 346_ YCKIP 351_ SCDSS 356_ PVSTE 361_ QLAPT 366_ APPEL 371_ TPVVQ 376_ DCYHG 381_ DGQSY 386_ RGTSS 391_ TTTTG 396_ KKCQS 401_ WSSMT 406_ PHRHQ 411_ KTPEN 416_ YPNAG 421_ LTMNY 426_ CRNPD 431_ ADKGP 436_ WCFTT 441_ DPSVR 446_ WEYCN 451_ LKKCS 456_ GTEAS 461_ VVAPP 466_ PVVLL 471_ PDVET 476_ PSEED 481_ CMFGN 486_ GKGYR 491_ GKRAT 496_ TVTGT 501_ PCQDW 506_ AAQEP 511_ HRHSI 516_ FTPET 521_ NPRAG 526_ LEKNY 531_ CRNPD 536_ GDVGG 541_ PWCYT 546_ TNPRK 551_ LYDYC 556_ DVPQC 561_ AAPSF 566_ DCGKP 571_ QVEPK 576_ KCPGR 581_ VVGGC 586_ VAHPH 591_ SWPWQ 596_ VSLRT 601_ RFGMH 606_ FCGGT 611_ LISPE 616_ WVLTA 621_ AHCLE 626_ KSPRP 631_ SSYKV 636_ ILGAH 641_ QEVNL 646_ EPHVQ 651_ EIEVS 656_ RLFLE 661_ PTRKD 666_ IALLK 671_ LSSPA 676_ VITDK 681_ VIPAC 686_ LPSPN 691_ YVVAD 696_ RTECF 701_ ITGWG 706_ ETQGT 711_ FGAGL 716_ LKEAQ 721_ LPVIE 726_ NKVCN 731_ RYEFL 736_ NGRVQ 741_ STELC 746_ AGHLA 751_ GGTDS 756_ CQGDS 761_ GGPLV 766_ CFEKD 771_ KYILQ 776_ GVTSW 781_ GLGCA 786_ RPNKP 791_ GVYVR 796_ VSRFV 801_TWIEG
1: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1, C4 and C5 (PubMed:6447255). Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells
2: Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo
3: (Microbial infection) ENO/enoloase from parasite P.falciparum (strain NF54) interacts with PLG present in the mosquito blood meal to promote the invasion of the mosquito midgut by the parasite ookinete (PubMed:21949403). The catalytic active form, plasmin, is essential for the invasion of the mosquito midgut (PubMed:21949403)
4: (Microbial infection) Binds to OspC on the surface of B.burgdorferi cells, possibly conferring an extracellular protease activity on the bacteria that allows it to traverse host tissue
5: (Microbial infection) Interacts with dengue virus type 2 particles (PubMed:31726374). Enhances dengue virus type 2 infection in Aedes aegypti mosquito midgut by increasing midgut internalization, resulting in higher infection rates and viral dissemination in mosquitoes (PubMed:31726374)