Coagulation factor XII (EC 3.4.21.38) (Hageman factor) (HAF) [Cleaved into: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Coagulation factor XIIa light chain (Beta-factor XIIa part 2)]
1_MRALL 6_ LLGFL 11_ LVSLE 16_ STLSI 21_ PPWEA 26_ PKEHK 31_ YKAEE 36_ HTVVL 41_ TVTGE 46_ PCHFP 51_ FQYHR 56_ QLYHK 61_ CTHKG 66_ RPGPQ 71_ PWCAT 76_ TPNFD 81_ QDQRW 86_ GYCLE 91_ PKKVK 96_ DHCSK 101_ HSPCQ 106_ KGGTC 111_ VNMPS 116_ GPHCL 121_ CPQHL 126_ TGNHC 131_ QKEKC 136_ FEPQL 141_ LRFFH 146_ KNEIW 151_ YRTEQ 156_ AAVAR 161_ CQCKG 166_ PDAHC 171_ QRLAS 176_ QACRT 181_ NPCLH 186_ GGRCL 191_ EVEGH 196_ RLCHC 201_ PVGYT 206_ GAFCD 211_ VDTKA 216_ SCYDG 221_ RGLSY 226_ RGLAR 231_ TTLSG 236_ APCQP 241_ WASEA 246_ TYRNV 251_ TAEQA 256_ RNWGL 261_ GGHAF 266_ CRNPD 271_ NDIRP 276_ WCFVL 281_ NRDRL 286_ SWEYC 291_ DLAQC 296_ QTPTQ 301_ AAPPT 306_ PVSPR 311_ LHVPL 316_ MPAQP 321_ APPKP 326_ QPTTR 331_ TPPQS 336_ QTPGA 341_ LPAKR 346_ EQPPS 351_ LTRNG 356_ PLSCG 361_ QRLRK 366_ SLSSM 371_ TRVVG 376_ GLVAL 381_ RGAHP 386_ YIAAL 391_ YWGHS 396_ FCAGS 401_ LIAPC 406_ WVLTA 411_ AHCLQ 416_ DRPAP 421_ EDLTV 426_ VLGQE 431_ RRNHS 436_ CEPCQ 441_ TLAVR 446_ SYRLH 451_ EAFSP 456_ VSYQH 461_ DLALL 466_ RLQED 471_ ADGSC 476_ ALLSP 481_ YVQPV 486_ CLPSG 491_ AARPS 496_ ETTLC 501_ QVAGW 506_ GHQFE 511_ GAEEY 516_ ASFLQ 521_ EAQVP 526_ FLSLE 531_ RCSAP 536_ DVHGS 541_ SILPG 546_ MLCAG 551_ FLEGG 556_ TDACQ 561_ GDSGG 566_ PLVCE 571_ DQAAE 576_ RRLTL 581_ QGIIS 586_ WGSGC 591_ GDRNK 596_ PGVYT 601_ DVAYY 606_LAWIR
1: Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (PubMed:2019570, PubMed:21304106, PubMed:8427954)