Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) (Alteplase) (Reteplase) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B]
1_MDAMK 6_ RGLCC 11_ VLLLC 16_ GAVFV 21_ SPSQE 26_ IHARF 31_ RRGAR 36_ SYQVI 41_ CRDEK 46_ TQMIY 51_ QQHQS 56_ WLRPV 61_ LRSNR 66_ VEYCW 71_ CNSGR 76_ AQCHS 81_ VPVKS 86_ CSEPR 91_ CFNGG 96_ TCQQA 101_ LYFSD 106_ FVCQC 111_ PEGFA 116_ GKCCE 121_ IDTRA 126_ TCYED 131_ QGISY 136_ RGTWS 141_ TAESG 146_ AECTN 151_ WNSSA 156_ LAQKP 161_ YSGRR 166_ PDAIR 171_ LGLGN 176_ HNYCR 181_ NPDRD 186_ SKPWC 191_ YVFKA 196_ GKYSS 201_ EFCST 206_ PACSE 211_ GNSDC 216_ YFGNG 221_ SAYRG 226_ THSLT 231_ ESGAS 236_ CLPWN 241_ SMILI 246_ GKVYT 251_ AQNPS 256_ AQALG 261_ LGKHN 266_ YCRNP 271_ DGDAK 276_ PWCHV 281_ LKNRR 286_ LTWEY 291_ CDVPS 296_ CSTCG 301_ LRQYS 306_ QPQFR 311_ IKGGL 316_ FADIA 321_ SHPWQ 326_ AAIFA 331_ KHRRS 336_ PGERF 341_ LCGGI 346_ LISSC 351_ WILSA 356_ AHCFQ 361_ ERFPP 366_ HHLTV 371_ ILGRT 376_ YRVVP 381_ GEEEQ 386_ KFEVE 391_ KYIVH 396_ KEFDD 401_ DTYDN 406_ DIALL 411_ QLKSD 416_ SSRCA 421_ QESSV 426_ VRTVC 431_ LPPAD 436_ LQLPD 441_ WTECE 446_ LSGYG 451_ KHEAL 456_ SPFYS 461_ ERLKE 466_ AHVRL 471_ YPSSR 476_ CTSQH 481_ LLNRT 486_ VTDNM 491_ LCAGD 496_ TRSGG 501_ PQANL 506_ HDACQ 511_ GDSGG 516_ PLVCL 521_ NDGRM 526_ TLVGI 531_ ISWGL 536_ GCGQK 541_ DVPGV 546_ YTKVT 551_ NYLDW 556_IRDNM
1: Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (By similarity)