Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)
1_MAQTP 6_ AFDKP 11_ KVELH 16_ VHLDG 21_ SIKPE 26_ TILYY 31_ GRRRG 36_ IALPA 41_ NTAEG 46_ LLNVI 51_ GMDKP 56_ LTLPD 61_ FLAKF 66_ DYYMP 71_ AIAGC 76_ REAIK 81_ RIAYE 86_ FVEMK 91_ AKEGV 96_ VYVEV 101_ RYSPH 106_ LLANS 111_ KVEPI 116_ PWNQA 121_ EGDLT 126_ PDEVV 131_ ALVGQ 136_ GLQEG 141_ ERDFG 146_ VKARS 151_ ILCCM 156_ RHQPN 161_ WSPKV 166_ VELCK 171_ KYQQQ 176_ TVVAI 181_ DLAGD 186_ ETIPG 191_ SSLLP 196_ GHVQA 201_ YQEAV 206_ KSGIH 211_ RTVHA 216_ GEVGS 221_ AEVVK 226_ EAVDI 231_ LKTER 236_ LGHGY 241_ HTLED 246_ QALYN 251_ RLRQE 256_ NMHFE 261_ ICPWS 266_ SYLTG 271_ AWKPD 276_ TEHAV 281_ IRLKN 286_ DQANY 291_ SLNTD 296_ DPLIF 301_ KSTLD 306_ TDYQM 311_ TKRDM 316_ GFTEE 321_ EFKRL 326_ NINAA 331_ KSSFL 336_ PEDEK 341_ RELLD 346_ LLYKA 351_ YGMPP 356_SASAG
1: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed:16670267, PubMed:23193172, PubMed:26166670, PubMed:8452534, PubMed:9361033). Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4 (PubMed:20959412). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation (PubMed:20959412). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (PubMed:23193172). Stimulates plasminogen activation (PubMed:15016824). Plays a role in male fertility (PubMed:21919946, PubMed:26166670). Plays a protective role in early postimplantation embryonic development (By similarity). Also responsible for the deamination of cordycepin (3'-deoxyadenosine), a fungal natural product that shows antitumor, antibacterial, antifungal, antivirus, and immune regulation properties (PubMed:26038697)