Alpha-1-antitrypsin (Alpha-1 protease inhibitor) (Alpha-1-antiproteinase) (Serpin A1) [Cleaved into: Short peptide from AAT (SPAAT)]
1_MPSSV 6_ SWGIL 11_ LLAGL 16_ CCLVP 21_ VSLAE 26_ DPQGD 31_ AAQKT 36_ DTSHH 41_ DQDHP 46_ TFNKI 51_ TPNLA 56_ EFAFS 61_ LYRQL 66_ AHQSN 71_ STNIF 76_ FSPVS 81_ IATAF 86_ AMLSL 91_ GTKAD 96_ THDEI 101_ LEGLN 106_ FNLTE 111_ IPEAQ 116_ IHEGF 121_ QELLR 126_ TLNQP 131_ DSQLQ 136_ LTTGN 141_ GLFLS 146_ EGLKL 151_ VDKFL 156_ EDVKK 161_ LYHSE 166_ AFTVN 171_ FGDTE 176_ EAKKQ 181_ INDYV 186_ EKGTQ 191_ GKIVD 196_ LVKEL 201_ DRDTV 206_ FALVN 211_ YIFFK 216_ GKWER 221_ PFEVK 226_ DTEEE 231_ DFHVD 236_ QVTTV 241_ KVPMM 246_ KRLGM 251_ FNIQH 256_ CKKLS 261_ SWVLL 266_ MKYLG 271_ NATAI 276_ FFLPD 281_ EGKLQ 286_ HLENE 291_ LTHDI 296_ ITKFL 301_ ENEDR 306_ RSASL 311_ HLPKL 316_ SITGT 321_ YDLKS 326_ VLGQL 331_ GITKV 336_ FSNGA 341_ DLSGV 346_ TEEAP 351_ LKLSK 356_ AVHKA 361_ VLTID 366_ EKGTE 371_ AAGAM 376_ FLEAI 381_ PMSIP 386_ PEVKF 391_ NKPFV 396_ FLMIE 401_ QNTKS 406_ PLFMG 411_KVVNP
1: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin
2: Reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE)