Angiotensinogen (Serpin A8) [Cleaved into: Angiotensin-1 (Angiotensin 1-10) (Angiotensin I) (Ang I); Angiotensin-2 (Angiotensin 1-8) (Angiotensin II) (Ang II); Angiotensin-3 (Angiotensin 2-8) (Angiotensin III) (Ang III) (Des-Asp[1]-angiotensin II); Angiotensin-4 (Angiotensin 3-8) (Angiotensin IV) (Ang IV); Angiotensin 1-9; Angiotensin 1-7; Angiotensin 1-5; Angiotensin 1-4]
1_MAPAG 6_ VSLRA 11_ TILCL 16_ LAWAG 21_ LAAGD 26_ RVYIH 31_ PFHLV 36_ IHNES 41_ TCEQL 46_ AKANA 51_ GKPKD 56_ PTFIP 61_ APIQA 66_ KTSPV 71_ DEKAL 76_ QDQLV 81_ LVAAK 86_ LDTED 91_ KLRAA 96_ MVGML 101_ ANFLG 106_ FRIYG 111_ MHSEL 116_ WGVVH 121_ GATVL 126_ SPTAV 131_ FGTLA 136_ SLYLG 141_ ALDHT 146_ ADRLQ 151_ AILGV 156_ PWKDK 161_ NCTSR 166_ LDAHK 171_ VLSAL 176_ QAVQG 181_ LLVAQ 186_ GRADS 191_ QAQLL 196_ LSTVV 201_ GVFTA 206_ PGLHL 211_ KQPFV 216_ QGLAL 221_ YTPVV 226_ LPRSL 231_ DFTEL 236_ DVAAE 241_ KIDRF 246_ MQAVT 251_ GWKTG 256_ CSLMG 261_ ASVDS 266_ TLAFN 271_ TYVHF 276_ QGKMK 281_ GFSLL 286_ AEPQE 291_ FWVDN 296_ STSVS 301_ VPMLS 306_ GMGTF 311_ QHWSD 316_ IQDNF 321_ SVTQV 326_ PFTES 331_ ACLLL 336_ IQPHY 341_ ASDLD 346_ KVEGL 351_ TFQQN 356_ SLNWM 361_ KKLSP 366_ RTIHL 371_ TMPQL 376_ VLQGS 381_ YDLQD 386_ LLAQA 391_ ELPAI 396_ LHTEL 401_ NLQKL 406_ SNDRI 411_ RVGEV 416_ LNSIF 421_ FELEA 426_ DEREP 431_ TESTQ 436_ QLNKP 441_ EVLEV 446_ TLNRP 451_ FLFAV 456_ YDQSA 461_ TALHF 466_ LGRVA 471_NPLST
1: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis
2: Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone (PubMed:10619573, PubMed:17138938). Acts by binding to angiotensin receptors AGTR1 and AGTR2 (PubMed:1567413). Also binds the DEAR/FBXW7-AS1 receptor (By similarity)
3: Stimulates aldosterone release
4: Is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets (By similarity)