Alpha-2-macroglobulin (Alpha-2-M) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5)
1_MGKNK 6_ LLHPS 11_ LVLLL 16_ LVLLP 21_ TDASV 26_ SGKPQ 31_ YMVLV 36_ PSLLH 41_ TETTE 46_ KGCVL 51_ LSYLN 56_ ETVTV 61_ SASLE 66_ SVRGN 71_ RSLFT 76_ DLEAE 81_ NDVLH 86_ CVAFA 91_ VPKSS 96_ SNEEV 101_ MFLTV 106_ QVKGP 111_ TQEFK 116_ KRTTV 121_ MVKNE 126_ DSLVF 131_ VQTDK 136_ SIYKP 141_ GQTVK 146_ FRVVS 151_ MDENF 156_ HPLNE 161_ LIPLV 166_ YIQDP 171_ KGNRI 176_ AQWQS 181_ FQLEG 186_ GLKQF 191_ SFPLS 196_ SEPFQ 201_ GSYKV 206_ VVQKK 211_ SGGRT 216_ EHPFT 221_ VEEFV 226_ LPKFE 231_ VQVTV 236_ PKIIT 241_ ILEEE 246_ MNVSV 251_ CGLYT 256_ YGKPV 261_ PGHVT 266_ VSICR 271_ KYSDA 276_ SDCHG 281_ EDSQA 286_ FCEKF 291_ SGQLN 296_ SHGCF 301_ YQQVK 306_ TKVFQ 311_ LKRKE 316_ YEMKL 321_ HTEAQ 326_ IQEEG 331_ TVVEL 336_ TGRQS 341_ SEITR 346_ TITKL 351_ SFVKV 356_ DSHFR 361_ QGIPF 366_ FGQVR 371_ LVDGK 376_ GVPIP 381_ NKVIF 386_ IRGNE 391_ ANYYS 396_ NATTD 401_ EHGLV 406_ QFSIN 411_ TTNVM 416_ GTSLT 421_ VRVNY 426_ KDRSP 431_ CYGYQ 436_ WVSEE 441_ HEEAH 446_ HTAYL 451_ VFSPS 456_ KSFVH 461_ LEPMS 466_ HELPC 471_ GHTQT 476_ VQAHY 481_ ILNGG 486_ TLLGL 491_ KKLSF 496_ YYLIM 501_ AKGGI 506_ VRTGT 511_ HGLLV 516_ KQEDM 521_ KGHFS 526_ ISIPV 531_ KSDIA 536_ PVARL 541_ LIYAV 546_ LPTGD 551_ VIGDS 556_ AKYDV 561_ ENCLA 566_ NKVDL 571_ SFSPS 576_ QSLPA 581_ SHAHL 586_ RVTAA 591_ PQSVC 596_ ALRAV 601_ DQSVL 606_ LMKPD 611_ AELSA 616_ SSVYN 621_ LLPEK 626_ DLTGF 631_ PGPLN 636_ DQDNE 641_ DCINR 646_ HNVYI 651_ NGITY 656_ TPVSS 661_ TNEKD 666_ MYSFL 671_ EDMGL 676_ KAFTN 681_ SKIRK 686_ PKMCP 691_ QLQQY 696_ EMHGP 701_ EGLRV 706_ GFYES 711_ DVMGR 716_ GHARL 721_ VHVEE 726_ PHTET 731_ VRKYF 736_ PETWI 741_ WDLVV 746_ VNSAG 751_ VAEVG 756_ VTVPD 761_ TITEW 766_ KAGAF 771_ CLSED 776_ AGLGI 781_ SSTAS 786_ LRAFQ 791_ PFFVE 796_ LTMPY 801_ SVIRG 806_ EAFTL 811_ KATVL 816_ NYLPK 821_ CIRVS 826_ VQLEA 831_ SPAFL 836_ AVPVE 841_ KEQAP 846_ HCICA 851_ NGRQT 856_ VSWAV 861_ TPKSL 866_ GNVNF 871_ TVSAE 876_ ALESQ 881_ ELCGT 886_ EVPSV 891_ PEHGR 896_ KDTVI 901_ KPLLV 906_ EPEGL 911_ EKETT 916_ FNSLL 921_ CPSGG 926_ EVSEE 931_ LSLKL 936_ PPNVV 941_ EESAR 946_ ASVSV 951_ LGDIL 956_ GSAMQ 961_ NTQNL 966_ LQMPY 971_ GCGEQ 976_ NMVLF 981_ APNIY 986_ VLDYL 991_ NETQQ 996_ LTPEI 1001_ KSKAI 1006_ GYLNT 1011_ GYQRQ 1016_ LNYKH 1021_ YDGSY 1026_ STFGE 1031_ RYGRN 1036_ QGNTW 1041_ LTAFV 1046_ LKTFA 1051_ QARAY 1056_ IFIDE 1061_ AHITQ 1066_ ALIWL 1071_ SQRQK 1076_ DNGCF 1081_ RSSGS 1086_ LLNNA 1091_ IKGGV 1096_ EDEVT 1101_ LSAYI 1106_ TIALL 1111_ EIPLT 1116_ VTHPV 1121_ VRNAL 1126_ FCLES 1131_ AWKTA 1136_ QEGDH 1141_ GSHVY 1146_ TKALL 1151_ AYAFA 1156_ LAGNQ 1161_ DKRKE 1166_ VLKSL 1171_ NEEAV 1176_ KKDNS 1181_ VHWER 1186_ PQKPK 1191_ APVGH 1196_ FYEPQ 1201_ APSAE 1206_ VEMTS 1211_ YVLLA 1216_ YLTAQ 1221_ PAPTS 1226_ EDLTS 1231_ ATNIV 1236_ KWITK 1241_ QQNAQ 1246_ GGFSS 1251_ TQDTV 1256_ VALHA 1261_ LSKYG 1266_ AATFT 1271_ RTGKA 1276_ AQVTI 1281_ QSSGT 1286_ FSSKF 1291_ QVDNN 1296_ NRLLL 1301_ QQVSL 1306_ PELPG 1311_ EYSMK 1316_ VTGEG 1321_ CVYLQ 1326_ TSLKY 1331_ NILPE 1336_ KEEFP 1341_ FALGV 1346_ QTLPQ 1351_ TCDEP 1356_ KAHTS 1361_ FQISL 1366_ SVSYT 1371_ GSRSA 1376_ SNMAI 1381_ VDVKM 1386_ VSGFI 1391_ PLKPT 1396_ VKMLE 1401_ RSNHV 1406_ SRTEV 1411_ SSNHV 1416_ LIYLD 1421_ KVSNQ 1426_ TLSLF 1431_ FTVLQ 1436_ DVPVR 1441_ DLKPA 1446_ IVKVY 1451_ DYYET 1456_ DEFAI 1461_ AEYNA 1466_PCSKD
1: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase