Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
1_MGPTS 6_ GPSLL 11_ LLLLT 16_ HLPLA 21_ LGSPM 26_ YSIIT 31_ PNILR 36_ LESEE 41_ TMVLE 46_ AHDAQ 51_ GDVPV 56_ TVTVH 61_ DFPGK 66_ KLVLS 71_ SEKTV 76_ LTPAT 81_ NHMGN 86_ VTFTI 91_ PANRE 96_ FKSEK 101_ GRNKF 106_ VTVQA 111_ TFGTQ 116_ VVEKV 121_ VLVSL 126_ QSGYL 131_ FIQTD 136_ KTIYT 141_ PGSTV 146_ LYRIF 151_ TVNHK 156_ LLPVG 161_ RTVMV 166_ NIENP 171_ EGIPV 176_ KQDSL 181_ SSQNQ 186_ LGVLP 191_ LSWDI 196_ PELVN 201_ MGQWK 206_ IRAYY 211_ ENSPQ 216_ QVFST 221_ EFEVK 226_ EYVLP 231_ SFEVI 236_ VEPTE 241_ KFYYI 246_ YNEKG 251_ LEVTI 256_ TARFL 261_ YGKKV 266_ EGTAF 271_ VIFGI 276_ QDGEQ 281_ RISLP 286_ ESLKR 291_ IPIED 296_ GSGEV 301_ VLSRK 306_ VLLDG 311_ VQNPR 316_ AEDLV 321_ GKSLY 326_ VSATV 331_ ILHSG 336_ SDMVQ 341_ AERSG 346_ IPIVT 351_ SPYQI 356_ HFTKT 361_ PKYFK 366_ PGMPF 371_ DLMVF 376_ VTNPD 381_ GSPAY 386_ RVPVA 391_ VQGED 396_ TVQSL 401_ TQGDG 406_ VAKLS 411_ INTHP 416_ SQKPL 421_ SITVR 426_ TKKQE 431_ LSEAE 436_ QATRT 441_ MQALP 446_ YSTVG 451_ NSNNY 456_ LHLSV 461_ LRTEL 466_ RPGET 471_ LNVNF 476_ LLRMD 481_ RAHEA 486_ KIRYY 491_ TYLIM 496_ NKGRL 501_ LKAGR 506_ QVREP 511_ GQDLV 516_ VLPLS 521_ ITTDF 526_ IPSFR 531_ LVAYY 536_ TLIGA 541_ SGQRE 546_ VVADS 551_ VWVDV 556_ KDSCV 561_ GSLVV 566_ KSGQS 571_ EDRQP 576_ VPGQQ 581_ MTLKI 586_ EGDHG 591_ ARVVL 596_ VAVDK 601_ GVFVL 606_ NKKNK 611_ LTQSK 616_ IWDVV 621_ EKADI 626_ GCTPG 631_ SGKDY 636_ AGVFS 641_ DAGLT 646_ FTSSS 651_ GQQTA 656_ QRAEL 661_ QCPQP 666_ AARRR 671_ RSVQL 676_ TEKRM 681_ DKVGK 686_ YPKEL 691_ RKCCE 696_ DGMRE 701_ NPMRF 706_ SCQRR 711_ TRFIS 716_ LGEAC 721_ KKVFL 726_ DCCNY 731_ ITELR 736_ RQHAR 741_ ASHLG 746_ LARSN 751_ LDEDI 756_ IAEEN 761_ IVSRS 766_ EFPES 771_ WLWNV 776_ EDLKE 781_ PPKNG 786_ ISTKL 791_ MNIFL 796_ KDSIT 801_ TWEIL 806_ AVSMS 811_ DKKGI 816_ CVADP 821_ FEVTV 826_ MQDFF 831_ IDLRL 836_ PYSVV 841_ RNEQV 846_ EIRAV 851_ LYNYR 856_ QNQEL 861_ KVRVE 866_ LLHNP 871_ AFCSL 876_ ATTKR 881_ RHQQT 886_ VTIPP 891_ KSSLS 896_ VPYVI 901_ VPLKT 906_ GLQEV 911_ EVKAA 916_ VYHHF 921_ ISDGV 926_ RKSLK 931_ VVPEG 936_ IRMNK 941_ TVAVR 946_ TLDPE 951_ RLGRE 956_ GVQKE 961_ DIPPA 966_ DLSDQ 971_ VPDTE 976_ SETRI 981_ LLQGT 986_ PVAQM 991_ TEDAV 996_ DAERL 1001_ KHLIV 1006_ TPSGC 1011_ GEQNM 1016_ IGMTP 1021_ TVIAV 1026_ HYLDE 1031_ TEQWE 1036_ KFGLE 1041_ KRQGA 1046_ LELIK 1051_ KGYTQ 1056_ QLAFR 1061_ QPSSA 1066_ FAAFV 1071_ KRAPS 1076_ TWLTA 1081_ YVVKV 1086_ FSLAV 1091_ NLIAI 1096_ DSQVL 1101_ CGAVK 1106_ WLILE 1111_ KQKPD 1116_ GVFQE 1121_ DAPVI 1126_ HQEMI 1131_ GGLRN 1136_ NNEKD 1141_ MALTA 1146_ FVLIS 1151_ LQEAK 1156_ DICEE 1161_ QVNSL 1166_ PGSIT 1171_ KAGDF 1176_ LEANY 1181_ MNLQR 1186_ SYTVA 1191_ IAGYA 1196_ LAQMG 1201_ RLKGP 1206_ LLNKF 1211_ LTTAK 1216_ DKNRW 1221_ EDPGK 1226_ QLYNV 1231_ EATSY 1236_ ALLAL 1241_ LQLKD 1246_ FDFVP 1251_ PVVRW 1256_ LNEQR 1261_ YYGGG 1266_ YGSTQ 1271_ ATFMV 1276_ FQALA 1281_ QYQKD 1286_ APDHQ 1291_ ELNLD 1296_ VSLQL 1301_ PSRSS 1306_ KITHR 1311_ IHWES 1316_ ASLLR 1321_ SEETK 1326_ ENEGF 1331_ TVTAE 1336_ GKGQG 1341_ TLSVV 1346_ TMYHA 1351_ KAKDQ 1356_ LTCNK 1361_ FDLKV 1366_ TIKPA 1371_ PETEK 1376_ RPQDA 1381_ KNTMI 1386_ LEICT 1391_ RYRGD 1396_ QDATM 1401_ SILDI 1406_ SMMTG 1411_ FAPDT 1416_ DDLKQ 1421_ LANGV 1426_ DRYIS 1431_ KYELD 1436_ KAFSD 1441_ RNTLI 1446_ IYLDK 1451_ VSHSE 1456_ DDCLA 1461_ FKVHQ 1466_ YFNVE 1471_ LIQPG 1476_ AVKVY 1481_ AYYNL 1486_ EESCT 1491_ RFYHP 1496_ EKEDG 1501_ KLNKL 1506_ CRDEL 1511_ CRCAE 1516_ ENCFI 1521_ QKSDD 1526_ KVTLE 1531_ ERLDK 1536_ ACEPG 1541_ VDYVY 1546_ KTRLV 1551_ KVQLS 1556_ NDFDE 1561_ YIMAI 1566_ EQTIK 1571_ SGSDE 1576_ VQVGQ 1581_ QRTFI 1586_ SPIKC 1591_ REALK 1596_ LEEKK 1601_ HYLMW 1606_ GLSSD 1611_ FWGEK 1616_ PNLSY 1621_ IIGKD 1626_ TWVEH 1631_ WPEED 1636_ ECQDE 1641_ ENQKQ 1646_ CQDLG 1651_ AFTES 1656_MVVFG
1: Precursor of non-enzymatic components of the classical, alternative, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system
2: Non-enzymatic component of C5 convertase (PubMed:28264884, PubMed:31507604, PubMed:3653927, PubMed:3897448). Generated following cleavage by C3 convertase, it covalently attaches to the surface of pathogens, where it acts as an opsonin that marks the surface of antigens for removal (PubMed:28264884, PubMed:31507604, PubMed:3653927, PubMed:3897448, PubMed:833545, PubMed:8349625). Complement C3b binds covalently via its reactive thioester, to cell surface carbohydrates or immune aggregates (PubMed:6903192). Together with complement C4b, it then recruits the serine protease complement C2b to form the C5 convertase, which cleaves and activate C5, the next component of the complement pathways (PubMed:12878586, PubMed:18204047, PubMed:2387864). In the alternative complement pathway, recruits the serine protease CFB to form the C5 convertase that cleaves and activates C5 (PubMed:624565, PubMed:6554279)
3: Mediator of local inflammatory process released following cleavage by C3 convertase (PubMed:6968751). Acts by binding to its receptor, C3AR1, activating G protein-coupled receptor signaling, promoting the phosphorylation, ARRB2-mediated internalization and endocytosis of C3AR1 (PubMed:8702752). C3a anaphylatoxin stimulates the activation of immune cells such as mast cells and basophilic leukocytes to release inflammation agents, such as cytokines, chemokines and histamine, which promote inflammation development (PubMed:23383423). Also acts as potent chemoattractant for the migration of macrophages and neutrophils to the inflamed tissues, resulting in neutralization of the inflammatory triggers by multiple ways, such as phagocytosis and generation of reactive oxidants (PubMed:23383423)
4: Adipogenic hormone that stimulates triglyceride synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial triglyceride clearance (PubMed:10432298, PubMed:15833747, PubMed:16333141, PubMed:19615750, PubMed:2909530, PubMed:8376604, PubMed:9059512). Appears to stimulate triglyceride synthesis via activation of the PLC, MAPK and AKT signaling pathways (PubMed:16333141). Acts by binding to its receptor, C5AR2, activating G protein-coupled receptor signaling, promoting the phosphorylation, ARRB2-mediated internalization and endocytosis of C5AR2 (PubMed:11773063, PubMed:12540846, PubMed:19615750)
5: Acts as a chemoattractant for neutrophils in chronic inflammation