Metalloproteinase inhibitor 1 (Erythroid-potentiating activity) (EPA) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) (Tissue inhibitor of metalloproteinases 1) (TIMP-1)
1_MAPFE 6_ PLASG 11_ ILLLL 16_ WLIAP 21_ SRACT 26_ CVPPH 31_ PQTAF 36_ CNSDL 41_ VIRAK 46_ FVGTP 51_ EVNQT 56_ TLYQR 61_ YEIKM 66_ TKMYK 71_ GFQAL 76_ GDAAD 81_ IRFVY 86_ TPAME 91_ SVCGY 96_ FHRSH 101_ NRSEE 106_ FLIAG 111_ KLQDG 116_ LLHIT 121_ TCSFV 126_ APWNS 131_ LSLAQ 136_ RRGFT 141_ KTYTV 146_ GCEEC 151_ TVFPC 156_ LSIPC 161_ KLQSG 166_ THCLW 171_ TDQLL 176_ QGSEK 181_ GFQSR 186_ HLACL 191_ PREPG 196_ LCTWQ 201_SLRSQ
1: Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors