Protein c-Fos (Cellular oncogene fos) (Fos proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 7) (Proto-oncogene c-Fos) (Transcription factor AP-1 subunit c-Fos)
1_MMFSG 6_ FNADY 11_ EASSS 16_ RCSSA 21_ SPAGD 26_ SLSYY 31_ HSPAD 36_ SFSSM 41_ GSPVN 46_ AQDFC 51_ TDLAV 56_ SSANF 61_ IPTVT 66_ AISTS 71_ PDLQW 76_ LVQPA 81_ LVSSV 86_ APSQT 91_ RAPHP 96_ FGVPA 101_ PSAGA 106_ YSRAG 111_ VVKTM 116_ TGGRA 121_ QSIGR 126_ RGKVE 131_ QLSPE 136_ EEEKR 141_ RIRRE 146_ RNKMA 151_ AAKCR 156_ NRRRE 161_ LTDTL 166_ QAETD 171_ QLEDE 176_ KSALQ 181_ TEIAN 186_ LLKEK 191_ EKLEF 196_ ILAAH 201_ RPACK 206_ IPDDL 211_ GFPEE 216_ MSVAS 221_ LDLTG 226_ GLPEV 231_ ATPES 236_ EEAFT 241_ LPLLN 246_ DPEPK 251_ PSVEP 256_ VKSIS 261_ SMELK 266_ TEPFD 271_ DFLFP 276_ ASSRP 281_ SGSET 286_ ARSVP 291_ DMDLS 296_ GSFYA 301_ ADWEP 306_ LHSGS 311_ LGMGP 316_ MATEL 321_ EPLCT 326_ PVVTC 331_ TPSCT 336_ AYTSS 341_ FVFTY 346_ PEADS 351_ FPSCA 356_ AAHRK 361_ GSSSN 366_ EPSSD 371_SLSSP
1: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum