Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
1_MPLNV 6_ SFTNR 11_ NYDLD 16_ YDSVQ 21_ PYFYC 26_ DEEEN 31_ FYQQQ 36_ QQSEL 41_ QPPAP 46_ SEDIW 51_ KKFEL 56_ LPTPP 61_ LSPSR 66_ RSGLC 71_ SPSYV 76_ AVTPF 81_ SLRGD 86_ NDGGG 91_ GSFST 96_ ADQLE 101_ MVTEL 106_ LGGDM 111_ VNQSF 116_ ICDPD 121_ DETFI 126_ KNIII 131_ QDCMW 136_ SGFSA 141_ AAKLV 146_ SEKLA 151_ SYQAA 156_ RKDSG 161_ SPNPA 166_ RGHSV 171_ CSTSS 176_ LYLQD 181_ LSAAA 186_ SECID 191_ PSVVF 196_ PYPLN 201_ DSSSP 206_ KSCAS 211_ QDSSA 216_ FSPSS 221_ DSLLS 226_ STESS 231_ PQGSP 236_ EPLVL 241_ HEETP 246_ PTTSS 251_ DSEEE 256_ QEDEE 261_ EIDVV 266_ SVEKR 271_ QAPGK 276_ RSESG 281_ SPSAG 286_ GHSKP 291_ PHSPL 296_ VLKRC 301_ HVSTH 306_ QHNYA 311_ APPST 316_ RKDYP 321_ AAKRV 326_ KLDSV 331_ RVLRQ 336_ ISNNR 341_ KCTSP 346_ RSSDT 351_ EENVK 356_ RRTHN 361_ VLERQ 366_ RRNEL 371_ KRSFF 376_ ALRDQ 381_ IPELE 386_ NNEKA 391_ PKVVI 396_ LKKAT 401_ AYILS 406_ VQAEE 411_ QKLIS 416_ EEDLL 421_ RKRRE 426_ QLKHK 431_LEQLR
1: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3' (PubMed:24940000, PubMed:25956029). Activates the transcription of growth-related genes (PubMed:24940000, PubMed:25956029). Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000, PubMed:25956029). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells (By similarity). Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808)