GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
1_MTEYK 6_ LVVVG 11_ AGGVG 16_ KSALT 21_ IQLIQ 26_ NHFVD 31_ EYDPT 36_ IEDSY 41_ RKQVV 46_ IDGET 51_ CLLDI 56_ LDTAG 61_ QEEYS 66_ AMRDQ 71_ YMRTG 76_ EGFLC 81_ VFAIN 86_ NTKSF 91_ EDIHH 96_ YREQI 101_ KRVKD 106_ SEDVP 111_ MVLVG 116_ NKCDL 121_ PSRTV 126_ DTKQA 131_ QDLAR 136_ SYGIP 141_ FIETS 146_ AKTRQ 151_ RVEDA 156_ FYTLV 161_ REIRQ 166_ YRLKK 171_ ISKEE 176_ KTPGC 181_VKIKK
1: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621, PubMed:39809765). Plays an important role in the regulation of cell proliferation (PubMed:22711838, PubMed:23698361). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306)