Platelet-derived growth factor subunit B (PDGF subunit B) (PDGF-2) (Platelet-derived growth factor B chain) (Platelet-derived growth factor beta polypeptide) (Proto-oncogene c-Sis) (Becaplermin)
1_MNRCW 6_ ALFLS 11_ LCCYL 16_ RLVSA 21_ EGDPI 26_ PEELY 31_ EMLSD 36_ HSIRS 41_ FDDLQ 46_ RLLHG 51_ DPGEE 56_ DGAEL 61_ DLNMT 66_ RSHSG 71_ GELES 76_ LARGR 81_ RSLGS 86_ LTIAE 91_ PAMIA 96_ ECKTR 101_ TEVFE 106_ ISRRL 111_ IDRTN 116_ ANFLV 121_ WPPCV 126_ EVQRC 131_ SGCCN 136_ NRNVQ 141_ CRPTQ 146_ VQLRP 151_ VQVRK 156_ IEIVR 161_ KKPIF 166_ KKATV 171_ TLEDH 176_ LACKC 181_ ETVAA 186_ ARPVT 191_ RSPGG 196_ SQEQR 201_ AKTPQ 206_ TRVTI 211_ RTVRV 216_ RRPPK 221_ GKHRK 226_ FKHTH 231_ DKTAL 236_KETLG
1: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin (PubMed:26599395). Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity)