Low-density lipoprotein receptor (LDL receptor)
1_MGPWG 6_ WKLRW 11_ TVALL 16_ LAAAG 21_ TAVGD 26_ RCERN 31_ EFQCQ 36_ DGKCI 41_ SYKWV 46_ CDGSA 51_ ECQDG 56_ SDESQ 61_ ETCLS 66_ VTCKS 71_ GDFSC 76_ GGRVN 81_ RCIPQ 86_ FWRCD 91_ GQVDC 96_ DNGSD 101_ EQGCP 106_ PKTCS 111_ QDEFR 116_ CHDGK 121_ CISRQ 126_ FVCDS 131_ DRDCL 136_ DGSDE 141_ ASCPV 146_ LTCGP 151_ ASFQC 156_ NSSTC 161_ IPQLW 166_ ACDND 171_ PDCED 176_ GSDEW 181_ PQRCR 186_ GLYVF 191_ QGDSS 196_ PCSAF 201_ EFHCL 206_ SGECI 211_ HSSWR 216_ CDGGP 221_ DCKDK 226_ SDEEN 231_ CAVAT 236_ CRPDE 241_ FQCSD 246_ GNCIH 251_ GSRQC 256_ DREYD 261_ CKDMS 266_ DEVGC 271_ VNVTL 276_ CEGPN 281_ KFKCH 286_ SGECI 291_ TLDKV 296_ CNMAR 301_ DCRDW 306_ SDEPI 311_ KECGT 316_ NECLD 321_ NNGGC 326_ SHVCN 331_ DLKIG 336_ YECLC 341_ PDGFQ 346_ LVAQR 351_ RCEDI 356_ DECQD 361_ PDTCS 366_ QLCVN 371_ LEGGY 376_ KCQCE 381_ EGFQL 386_ DPHTK 391_ ACKAV 396_ GSIAY 401_ LFFTN 406_ RHEVR 411_ KMTLD 416_ RSEYT 421_ SLIPN 426_ LRNVV 431_ ALDTE 436_ VASNR 441_ IYWSD 446_ LSQRM 451_ ICSTQ 456_ LDRAH 461_ GVSSY 466_ DTVIS 471_ RDIQA 476_ PDGLA 481_ VDWIH 486_ SNIYW 491_ TDSVL 496_ GTVSV 501_ ADTKG 506_ VKRKT 511_ LFREN 516_ GSKPR 521_ AIVVD 526_ PVHGF 531_ MYWTD 536_ WGTPA 541_ KIKKG 546_ GLNGV 551_ DIYSL 556_ VTENI 561_ QWPNG 566_ ITLDL 571_ LSGRL 576_ YWVDS 581_ KLHSI 586_ SSIDV 591_ NGGNR 596_ KTILE 601_ DEKRL 606_ AHPFS 611_ LAVFE 616_ DKVFW 621_ TDIIN 626_ EAIFS 631_ ANRLT 636_ GSDVN 641_ LLAEN 646_ LLSPE 651_ DMVLF 656_ HNLTQ 661_ PRGVN 666_ WCERT 671_ TLSNG 676_ GCQYL 681_ CLPAP 686_ QINPH 691_ SPKFT 696_ CACPD 701_ GMLLA 706_ RDMRS 711_ CLTEA 716_ EAAVA 721_ TQETS 726_ TVRLK 731_ VSSTA 736_ VRTQH 741_ TTTRP 746_ VPDTS 751_ RLPGA 756_ TPGLT 761_ TVEIV 766_ TMSHQ 771_ ALGDV 776_ AGRGN 781_ EKKPS 786_ SVRAL 791_ SIVLP 796_ IVLLV 801_ FLCLG 806_ VFLLW 811_ KNWRL 816_ KNINS 821_ INFDN 826_ PVYQK 831_ TTEDE 836_ VHICH 841_ NQDGY 846_ SYPSR 851_QMVSL
1: Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization (PubMed:30443021)
2: (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins
3: (Microbial infection) Acts as a receptor for Vesicular stomatitis virus
4: (Microbial infection) In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells
5: (Microbial infection) Acts as a receptor for Crimean-Congo hemorrhagic fever virus (CCHFV)
6: (Microbial infection) Acts as a receptor for many Alphavirus, including Getah virus (GETV), Ross river virus (RRV) and Semliki Forest virus