VIP peptides [Cleaved into: Intestinal peptide PHV-42 (Peptide histidine valine 42); Intestinal peptide PHM-27 (Peptide histidine methioninamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide)]
1_MDTRN 6_ KAQLL 11_ VLLTL 16_ LSVLF 21_ SQTSA 26_ WPLYR 31_ APSAL 36_ RLGDR 41_ IPFEG 46_ ANEPD 51_ QVSLK 56_ EDIDM 61_ LQNAL 66_ AENDT 71_ PYYDV 76_ SRNAR 81_ HADGV 86_ FTSDF 91_ SKLLG 96_ QLSAK 101_ KYLES 106_ LMGKR 111_ VSSNI 116_ SEDPV 121_ PVKRH 126_ SDAVF 131_ TDNYT 136_ RLRKQ 141_ MAVKK 146_ YLNSI 151_ LNGKR 156_ SSEGE 161_SPDFP
1: VIP is a neuropeptide involved in a diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2) (PubMed:1318039, PubMed:36385145, PubMed:8933357). Abundantly expressed throughout the CNS and peripheral nervous systems where they primarily exert neuroprotective and immune modulatory roles (PubMed:3456568). Also causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder (PubMed:15013843)
2: PHM-27 and PHV-42 are two bioactive forms from proteolysis of the same precursor protein, that cause vasodilation (PubMed:15013843, PubMed:3654650). PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin (PubMed:15013843)