Interferon beta (IFN-beta) (Fibroblast interferon)
1_MTNKC 6_ LLQIA 11_ LLLCF 16_ STTAL 21_ SMSYN 26_ LLGFL 31_ QRSSN 36_ FQCQK 41_ LLWQL 46_ NGRLE 51_ YCLKD 56_ RMNFD 61_ IPEEI 66_ KQLQQ 71_ FQKED 76_ AALTI 81_ YEMLQ 86_ NIFAI 91_ FRQDS 96_ SSTGW 101_ NETIV 106_ ENLLA 111_ NVYHQ 116_ INHLK 121_ TVLEE 126_ KLEKE 131_ DFTRG 136_ KLMSS 141_ LHLKR 146_ YYGRI 151_ LHYLK 156_ AKEYS 161_ HCAWT 166_ IVRVE 171_ ILRNF 176_ YFINR 181_LTGYL
1: Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli (PubMed:10049744, PubMed:10556041, PubMed:6157094, PubMed:6171735, PubMed:7665574, PubMed:8027027, PubMed:8969169). Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins (PubMed:10049744, PubMed:10556041, PubMed:7665574, PubMed:8027027, PubMed:8969169). Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways (By similarity). Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor (By similarity). Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss (By similarity). IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity)