Interleukin-1 beta (IL-1 beta) (Catabolin)
1_MAEVP 6_ ELASE 11_ MMAYY 16_ SGNED 21_ DLFFE 26_ ADGPK 31_ QMKCS 36_ FQDLD 41_ LCPLD 46_ GGIQL 51_ RISDH 56_ HYSKG 61_ FRQAA 66_ SVVVA 71_ MDKLR 76_ KMLVP 81_ CPQTF 86_ QENDL 91_ STFFP 96_ FIFEE 101_ EPIFF 106_ DTWDN 111_ EAYVH 116_ DAPVR 121_ SLNCT 126_ LRDSQ 131_ QKSLV 136_ MSGPY 141_ ELKAL 146_ HLQGQ 151_ DMEQQ 156_ VVFSM 161_ SFVQG 166_ EESND 171_ KIPVA 176_ LGLKE 181_ KNLYL 186_ SCVLK 191_ DDKPT 196_ LQLES 201_ VDPKN 206_ YPKKK 211_ MEKRF 216_ VFNKI 221_ EINNK 226_ LEFES 231_ AQFPN 236_ WYIST 241_ SQAEN 246_ MPVFL 251_ GGTKG 256_ GQDIT 261_DFTMQ
1: Potent pro-inflammatory cytokine (PubMed:10653850, PubMed:12794819, PubMed:28331908, PubMed:3920526). Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production (PubMed:3920526). Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6 (PubMed:12794819). Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33377178, PubMed:33883744). Acts as a sensor of S.pyogenes infection in skin: cleaved and activated by pyogenes SpeB protease, leading to an inflammatory response that prevents bacterial growth during invasive skin infection (PubMed:28331908)