Gene name: EPO

Uniprot entry:

P01588

Protein names:

Erythropoietin (Epoetin)

Protein sequence:

1_MGVHE 6_ CPAWL 11_ WLLLS 16_ LLSLP 21_ LGLPV 26_ LGAPP 31_ RLICD 36_ SRVLE 41_ RYLLE 46_ AKEAE 51_ NITTG 56_ CAEHC 61_ SLNEN 66_ ITVPD 71_ TKVNF 76_ YAWKR 81_ MEVGQ 86_ QAVEV 91_ WQGLA 96_ LLSEA 101_ VLRGQ 106_ ALLVN 111_ SSQPW 116_ EPLQL 121_ HVDKA 126_ VSGLR 131_ SLTTL 136_ LRALG 141_ AQKEA 146_ ISPPD 151_ AASAA 156_ PLRTI 161_ TADTF 166_ RKLFR 171_ VYSNF 176_ LRGKL 181_ KLYTG 186_EACRT

Protein annotations

Protein functions:

1: Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass (PubMed:28283061). Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3 (PubMed:9774108)