Immunoglobulin lambda variable 1-47 (Ig lambda chain V-I region HA) (Ig lambda chain V-I region WAH)
1_MAGFP 6_ LLLTL 11_ LTHCA 16_ GSWAQ 21_ SVLTQ 26_ PPSAS 31_ GTPGQ 36_ RVTIS 41_ CSGSS 46_ SNIGS 51_ NYVYW 56_ YQQLP 61_ GTAPK 66_ LLIYS 71_ NNQRP 76_ SGVPD 81_ RFSGS 86_ KSGTS 91_ ASLAI 96_ SGLRS 101_ EDEAD 106_ YYCAA 111_WDDSL
1: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)