Immunoglobulin lambda variable 1-51 (Ig lambda chain V-I region BL2) (Ig lambda chain V-I region EPS) (Ig lambda chain V-I region NEW) (Ig lambda chain V-I region NIG-64)
1_MTCSP 6_ LLLTL 11_ LIHCT 16_ GSWAQ 21_ SVLTQ 26_ PPSVS 31_ AAPGQ 36_ KVTIS 41_ CSGSS 46_ SNIGN 51_ NYVSW 56_ YQQLP 61_ GTAPK 66_ LLIYD 71_ NNKRP 76_ SGIPD 81_ RFSGS 86_ KSGTS 91_ ATLGI 96_ TGLQT 101_ GDEAD 106_ YYCGT 111_WDSSL
1: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)