Immunoglobulin lambda variable 1-40 (Ig lambda chain V-I region NEWM)
1_MAWSP 6_ LLLTL 11_ LAHCT 16_ GSWAQ 21_ SVLTQ 26_ PPSVS 31_ GAPGQ 36_ RVTIS 41_ CTGSS 46_ SNIGA 51_ GYDVH 56_ WYQQL 61_ PGTAP 66_ KLLIY 71_ GNSNR 76_ PSGVP 81_ DRFSG 86_ SKSGT 91_ SASLA 96_ ITGLQ 101_ AEDEA 106_ DYYCQ 111_SYDSS
1: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)