Gene name: MB

Uniprot entry:

P02144

Protein names:

Myoglobin

Protein sequence:

1_MGLSD 6_ GEWQL 11_ VLNVW 16_ GKVEA 21_ DIPGH 26_ GQEVL 31_ IRLFK 36_ GHPET 41_ LEKFD 46_ KFKHL 51_ KSEDE 56_ MKASE 61_ DLKKH 66_ GATVL 71_ TALGG 76_ ILKKK 81_ GHHEA 86_ EIKPL 91_ AQSHA 96_ TKHKI 101_ PVKYL 106_ EFISE 111_ CIIQV 116_ LQSKH 121_ PGDFG 126_ ADAQG 131_ AMNKA 136_ LELFR 141_ KDMAS 146_NYKEL

Protein annotations

Protein functions:

1: Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand (PubMed:30918256, PubMed:34679218). Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide (PubMed:32891753). Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity (PubMed:34679218)