Collagen alpha-1(IV) chain [Cleaved into: Arresten]
1_MGPRL 6_ SVWLL 11_ LLPAA 16_ LLLHE 21_ EHSRA 26_ AAKGG 31_ CAGSG 36_ CGKCD 41_ CHGVK 46_ GQKGE 51_ RGLPG 56_ LQGVI 61_ GFPGM 66_ QGPEG 71_ PQGPP 76_ GQKGD 81_ TGEPG 86_ LPGTK 91_ GTRGP 96_ PGASG 101_ YPGNP 106_ GLPGI 111_ PGQDG 116_ PPGPP 121_ GIPGC 126_ NGTKG 131_ ERGPL 136_ GPPGL 141_ PGFAG 146_ NPGPP 151_ GLPGM 156_ KGDPG 161_ EILGH 166_ VPGML 171_ LKGER 176_ GFPGI 181_ PGTPG 186_ PPGLP 191_ GLQGP 196_ VGPPG 201_ FTGPP 206_ GPPGP 211_ PGPPG 216_ EKGQM 221_ GLSFQ 226_ GPKGD 231_ KGDQG 236_ VSGPP 241_ GVPGQ 246_ AQVQE 251_ KGDFA 256_ TKGEK 261_ GQKGE 266_ PGFQG 271_ MPGVG 276_ EKGEP 281_ GKPGP 286_ RGKPG 291_ KDGDK 296_ GEKGS 301_ PGFPG 306_ EPGYP 311_ GLIGR 316_ QGPQG 321_ EKGEA 326_ GPPGP 331_ PGIVI 336_ GTGPL 341_ GEKGE 346_ RGYPG 351_ TPGPR 356_ GEPGP 361_ KGFPG 366_ LPGQP 371_ GPPGL 376_ PVPGQ 381_ AGAPG 386_ FPGER 391_ GEKGD 396_ RGFPG 401_ TSLPG 406_ PSGRD 411_ GLPGP 416_ PGSPG 421_ PPGQP 426_ GYTNG 431_ IVECQ 436_ PGPPG 441_ DQGPP 446_ GIPGQ 451_ PGFIG 456_ EIGEK 461_ GQKGE 466_ SCLIC 471_ DIDGY 476_ RGPPG 481_ PQGPP 486_ GEIGF 491_ PGQPG 496_ AKGDR 501_ GLPGR 506_ DGVAG 511_ VPGPQ 516_ GTPGL 521_ IGQPG 526_ AKGEP 531_ GEFYF 536_ DLRLK 541_ GDKGD 546_ PGFPG 551_ QPGMP 556_ GRAGS 561_ PGRDG 566_ HPGLP 571_ GPKGS 576_ PGSVG 581_ LKGER 586_ GPPGG 591_ VGFPG 596_ SRGDT 601_ GPPGP 606_ PGYGP 611_ AGPIG 616_ DKGQA 621_ GFPGG 626_ PGSPG 631_ LPGPK 636_ GEPGK 641_ IVPLP 646_ GPPGA 651_ EGLPG 656_ SPGFP 661_ GPQGD 666_ RGFPG 671_ TPGRP 676_ GLPGE 681_ KGAVG 686_ QPGIG 691_ FPGPP 696_ GPKGV 701_ DGLPG 706_ DMGPP 711_ GTPGR 716_ PGFNG 721_ LPGNP 726_ GVQGQ 731_ KGEPG 736_ VGLPG 741_ LKGLP 746_ GLPGI 751_ PGTPG 756_ EKGSI 761_ GVPGV 766_ PGEHG 771_ AIGPP 776_ GLQGI 781_ RGEPG 786_ PPGLP 791_ GSVGS 796_ PGVPG 801_ IGPPG 806_ ARGPP 811_ GGQGP 816_ PGLSG 821_ PPGIK 826_ GEKGF 831_ PGFPG 836_ LDMPG 841_ PKGDK 846_ GAQGL 851_ PGITG 856_ QSGLP 861_ GLPGQ 866_ QGAPG 871_ IPGFP 876_ GSKGE 881_ MGVMG 886_ TPGQP 891_ GSPGP 896_ VGAPG 901_ LPGEK 906_ GDHGF 911_ PGSSG 916_ PRGDP 921_ GLKGD 926_ KGDVG 931_ LPGKP 936_ GSMDK 941_ VDMGS 946_ MKGQK 951_ GDQGE 956_ KGQIG 961_ PIGEK 966_ GSRGD 971_ PGTPG 976_ VPGKD 981_ GQAGQ 986_ PGQPG 991_ PKGDP 996_ GISGT 1001_ PGAPG 1006_ LPGPK 1011_ GSVGG 1016_ MGLPG 1021_ TPGEK 1026_ GVPGI 1031_ PGPQG 1036_ SPGLP 1041_ GDKGA 1046_ KGEKG 1051_ QAGPP 1056_ GIGIP 1061_ GLRGE 1066_ KGDQG 1071_ IAGFP 1076_ GSPGE 1081_ KGEKG 1086_ SIGIP 1091_ GMPGS 1096_ PGLKG 1101_ SPGSV 1106_ GYPGS 1111_ PGLPG 1116_ EKGDK 1121_ GLPGL 1126_ DGIPG 1131_ VKGEA 1136_ GLPGT 1141_ PGPTG 1146_ PAGQK 1151_ GEPGS 1156_ DGIPG 1161_ SAGEK 1166_ GEPGL 1171_ PGRGF 1176_ PGFPG 1181_ AKGDK 1186_ GSKGE 1191_ VGFPG 1196_ LAGSP 1201_ GIPGS 1206_ KGEQG 1211_ FMGPP 1216_ GPQGQ 1221_ PGLPG 1226_ SPGHA 1231_ TEGPK 1236_ GDRGP 1241_ QGQPG 1246_ LPGLP 1251_ GPMGP 1256_ PGLPG 1261_ IDGVK 1266_ GDKGN 1271_ PGWPG 1276_ APGVP 1281_ GPKGD 1286_ PGFQG 1291_ MPGIG 1296_ GSPGI 1301_ TGSKG 1306_ DMGPP 1311_ GVPGF 1316_ QGPKG 1321_ LPGLQ 1326_ GIKGD 1331_ QGDQG 1336_ VPGAK 1341_ GLPGP 1346_ PGPPG 1351_ PYDII 1356_ KGEPG 1361_ LPGPE 1366_ GPPGL 1371_ KGLQG 1376_ LPGPK 1381_ GQQGV 1386_ TGLVG 1391_ IPGPP 1396_ GIPGF 1401_ DGAPG 1406_ QKGEM 1411_ GPAGP 1416_ TGPRG 1421_ FPGPP 1426_ GPDGL 1431_ PGSMG 1436_ PPGTP 1441_ SVDHG 1446_ FLVTR 1451_ HSQTI 1456_ DDPQC 1461_ PSGTK 1466_ ILYHG 1471_ YSLLY 1476_ VQGNE 1481_ RAHGQ 1486_ DLGTA 1491_ GSCLR 1496_ KFSTM 1501_ PFLFC 1506_ NINNV 1511_ CNFAS 1516_ RNDYS 1521_ YWLST 1526_ PEPMP 1531_ MSMAP 1536_ ITGEN 1541_ IRPFI 1546_ SRCAV 1551_ CEAPA 1556_ MVMAV 1561_ HSQTI 1566_ QIPPC 1571_ PSGWS 1576_ SLWIG 1581_ YSFVM 1586_ HTSAG 1591_ AEGSG 1596_ QALAS 1601_ PGSCL 1606_ EEFRS 1611_ APFIE 1616_ CHGRG 1621_ TCNYY 1626_ ANAYS 1631_ FWLAT 1636_ IERSE 1641_ MFKKP 1646_ TPSTL 1651_ KAGEL 1656_ RTHVS 1661_RCQVC
1: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen
2: Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation