Alpha-crystallin A chain (Heat shock protein beta-4) (HspB4) [Cleaved into: Alpha-crystallin A(1-172); Alpha-crystallin A(1-168); Alpha-crystallin A(1-162)]
1_MDVTI 6_ QHPWF 11_ KRTLG 16_ PFYPS 21_ RLFDQ 26_ FFGEG 31_ LFEYD 36_ LLPFL 41_ SSTIS 46_ PYYRQ 51_ SLFRT 56_ VLDSG 61_ ISEVR 66_ SDRDK 71_ FVIFL 76_ DVKHF 81_ SPEDL 86_ TVKVQ 91_ DDFVE 96_ IHGKH 101_ NERQD 106_ DHGYI 111_ SREFH 116_ RRYRL 121_ PSNVD 126_ QSALS 131_ CSLSA 136_ DGMLT 141_ FCGPK 146_ IQTGL 151_ DATHA 156_ ERAIP 161_ VSREE 166_KPTSA
1: Contributes to the transparency and refractive index of the lens (PubMed:18302245). In its oxidized form (absence of intramolecular disulfide bond), acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions (PubMed:18199971, PubMed:19595763, PubMed:22120592, PubMed:31792453). Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (PubMed:28935373)