Apolipoprotein C-I (Apo-CI) (ApoC-I) (Apolipoprotein C1) [Cleaved into: Truncated apolipoprotein C-I]
1_MRLFL 6_ SLPVL 11_ VVVLS 16_ IVLEG 21_ PAPAQ 26_ GTPDV 31_ SSALD 36_ KLKEF 41_ GNTLE 46_ DKARE 51_ LISRI 56_ KQSEL 61_ SAKMR 66_ EWFSE 71_ TFQKV 76_KEKLK
1: Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein