Apolipoprotein C-III (Apo-CIII) (ApoC-III) (Apolipoprotein C3)
1_MQPRV 6_ LLVVA 11_ LLALL 16_ ASARA 21_ SEAED 26_ ASLLS 31_ FMQGY 36_ MKHAT 41_ KTAKD 46_ ALSSV 51_ QESQV 56_ AQQAR 61_ GWVTD 66_ GFSSL 71_ KDYWS 76_ TVKDK 81_ FSEFW 86_ DLDPE 91_VRPTS
1: Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma (PubMed:18201179, PubMed:22510806). Plays a multifaceted role in triglyceride homeostasis (PubMed:18201179, PubMed:22510806). Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs) (PubMed:18201179, PubMed:22510806). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors (PubMed:18201179, PubMed:22510806). Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners (PubMed:18408013)