Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]
1_MFSMR 6_ IVCLV 11_ LSVVG 16_ TAWTA 21_ DSGEG 26_ DFLAE 31_ GGGVR 36_ GPRVV 41_ ERHQS 46_ ACKDS 51_ DWPFC 56_ SDEDW 61_ NYKCP 66_ SGCRM 71_ KGLID 76_ EVNQD 81_ FTNRI 86_ NKLKN 91_ SLFEY 96_ QKNNK 101_ DSHSL 106_ TTNIM 111_ EILRG 116_ DFSSA 121_ NNRDN 126_ TYNRV 131_ SEDLR 136_ SRIEV 141_ LKRKV 146_ IEKVQ 151_ HIQLL 156_ QKNVR 161_ AQLVD 166_ MKRLE 171_ VDIDI 176_ KIRSC 181_ RGSCS 186_ RALAR 191_ EVDLK 196_ DYEDQ 201_ QKQLE 206_ QVIAK 211_ DLLPS 216_ RDRQH 221_ LPLIK 226_ MKPVP 231_ DLVPG 236_ NFKSQ 241_ LQKVP 246_ PEWKA 251_ LTDMP 256_ QMRME 261_ LERPG 266_ GNEIT 271_ RGGST 276_ SYGTG 281_ SETES 286_ PRNPS 291_ SAGSW 296_ NSGSS 301_ GPGST 306_ GNRNP 311_ GSSGT 316_ GGTAT 321_ WKPGS 326_ SGPGS 331_ TGSWN 336_ SGSSG 341_ TGSTG 346_ NQNPG 351_ SPRPG 356_ STGTW 361_ NPGSS 366_ ERGSA 371_ GHWTS 376_ ESSVS 381_ GSTGQ 386_ WHSES 391_ GSFRP 396_ DSPGS 401_ GNARP 406_ NNPDW 411_ GTFEE 416_ VSGNV 421_ SPGTR 426_ REYHT 431_ EKLVT 436_ SKGDK 441_ ELRTG 446_ KEKVT 451_ SGSTT 456_ TTRRS 461_ CSKTV 466_ TKTVI 471_ GPDGH 476_ KEVTK 481_ EVVTS 486_ EDGSD 491_ CPEAM 496_ DLGTL 501_ SGIGT 506_ LDGFR 511_ HRHPD 516_ EAAFF 521_ DTAST 526_ GKTFP 531_ GFFSP 536_ MLGEF 541_ VSETE 546_ SRGSE 551_ SGIFT 556_ NTKES 561_ SSHHP 566_ GIAEF 571_ PSRGK 576_ SSSYS 581_ KQFTS 586_ STSYN 591_ RGDST 596_ FESKS 601_ YKMAD 606_ EAGSE 611_ ADHEG 616_ THSTK 621_ RGHAK 626_ SRPVR 631_ DCDDV 636_ LQTHP 641_ SGTQS 646_ GIFNI 651_ KLPGS 656_ SKIFS 661_ VYCDQ 666_ ETSLG 671_ GWLLI 676_ QQRMD 681_ GSLNF 686_ NRTWQ 691_ DYKRG 696_ FGSLN 701_ DEGEG 706_ EFWLG 711_ NDYLH 716_ LLTQR 721_ GSVLR 726_ VELED 731_ WAGNE 736_ AYAEY 741_ HFRVG 746_ SEAEG 751_ YALQV 756_ SSYEG 761_ TAGDA 766_ LIEGS 771_ VEEGA 776_ EYTSH 781_ NNMQF 786_ STFDR 791_ DADQW 796_ EENCA 801_ EVYGG 806_ GWWYN 811_ NCQAA 816_ NLNGI 821_ YYPGG 826_ SYDPR 831_ NNSPY 836_ EIENG 841_ VVWVS 846_ FRGAD 851_ YSLRA 856_ VRMKI 861_RPLVT
1: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways