Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]
1_MKRMV 6_ SWSFH 11_ KLKTM 16_ KHLLL 21_ LLLCV 26_ FLVKS 31_ QGVND 36_ NEEGF 41_ FSARG 46_ HRPLD 51_ KKREE 56_ APSLR 61_ PAPPP 66_ ISGGG 71_ YRARP 76_ AKAAA 81_ TQKKV 86_ ERKAP 91_ DAGGC 96_ LHADP 101_ DLGVL 106_ CPTGC 111_ QLQEA 116_ LLQQE 121_ RPIRN 126_ SVDEL 131_ NNNVE 136_ AVSQT 141_ SSSSF 146_ QYMYL 151_ LKDLW 156_ QKRQK 161_ QVKDN 166_ ENVVN 171_ EYSSE 176_ LEKHQ 181_ LYIDE 186_ TVNSN 191_ IPTNL 196_ RVLRS 201_ ILENL 206_ RSKIQ 211_ KLESD 216_ VSAQM 221_ EYCRT 226_ PCTVS 231_ CNIPV 236_ VSGKE 241_ CEEII 246_ RKGGE 251_ TSEMY 256_ LIQPD 261_ SSVKP 266_ YRVYC 271_ DMNTE 276_ NGGWT 281_ VIQNR 286_ QDGSV 291_ DFGRK 296_ WDPYK 301_ QGFGN 306_ VATNT 311_ DGKNY 316_ CGLPG 321_ EYWLG 326_ NDKIS 331_ QLTRM 336_ GPTEL 341_ LIEME 346_ DWKGD 351_ KVKAH 356_ YGGFT 361_ VQNEA 366_ NKYQI 371_ SVNKY 376_ RGTAG 381_ NALMD 386_ GASQL 391_ MGENR 396_ TMTIH 401_ NGMFF 406_ STYDR 411_ DNDGW 416_ LTSDP 421_ RKQCS 426_ KEDGG 431_ GWWYN 436_ RCHAA 441_ NPNGR 446_ YYWGG 451_ QYTWD 456_ MAKHG 461_ TDDGV 466_ VWMNW 471_ KGSWY 476_ SMRKM 481_ SMKIR 486_PFFPQ
1: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways