Fibrinogen gamma chain
1_MSWSL 6_ HPRNL 11_ ILYFY 16_ ALLFL 21_ SSTCV 26_ AYVAT 31_ RDNCC 36_ ILDER 41_ FGSYC 46_ PTTCG 51_ IADFL 56_ STYQT 61_ KVDKD 66_ LQSLE 71_ DILHQ 76_ VENKT 81_ SEVKQ 86_ LIKAI 91_ QLTYN 96_ PDESS 101_ KPNMI 106_ DAATL 111_ KSRKM 116_ LEEIM 121_ KYEAS 126_ ILTHD 131_ SSIRY 136_ LQEIY 141_ NSNNQ 146_ KIVNL 151_ KEKVA 156_ QLEAQ 161_ CQEPC 166_ KDTVQ 171_ IHDIT 176_ GKDCQ 181_ DIANK 186_ GAKQS 191_ GLYFI 196_ KPLKA 201_ NQQFL 206_ VYCEI 211_ DGSGN 216_ GWTVF 221_ QKRLD 226_ GSVDF 231_ KKNWI 236_ QYKEG 241_ FGHLS 246_ PTGTT 251_ EFWLG 256_ NEKIH 261_ LISTQ 266_ SAIPY 271_ ALRVE 276_ LEDWN 281_ GRTST 286_ ADYAM 291_ FKVGP 296_ EADKY 301_ RLTYA 306_ YFAGG 311_ DAGDA 316_ FDGFD 321_ FGDDP 326_ SDKFF 331_ TSHNG 336_ MQFST 341_ WDNDN 346_ DKFEG 351_ NCAEQ 356_ DGSGW 361_ WMNKC 366_ HAGHL 371_ NGVYY 376_ QGGTY 381_ SKAST 386_ PNGYD 391_ NGIIW 396_ ATWKT 401_ RWYSM 406_ KKTTM 411_ KIIPF 416_ NRLTI 421_ GEGQQ 426_ HHLGG 431_ AKQVR 436_ PEHPA 441_ ETEYD 446_SLYPE
1: Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways