Glycophorin-A (MN sialoglycoprotein) (PAS-2) (Sialoglycoprotein alpha) (CD antigen CD235a)
1_MYGKI 6_ IFVLL 11_ LSEIV 16_ SISAS 21_ STTGV 26_ AMHTS 31_ TSSSV 36_ TKSYI 41_ SSQTN 46_ DTHKR 51_ DTYAA 56_ TPRAH 61_ EVSEI 66_ SVRTV 71_ YPPEE 76_ ETGER 81_ VQLAH 86_ HFSEP 91_ EITLI 96_ IFGVM 101_ AGVIG 106_ TILLI 111_ SYGIR 116_ RLIKK 121_ SPSDV 126_ KPLPS 131_ PDTDV 136_ PLSSV 141_EIENP
1: Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865). Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane
2: (Microbial infection) Appears to be a receptor for Hepatitis A virus (HAV)
3: (Microbial infection) Receptor for P.falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans