Complement component C9 [Cleaved into: Complement component C9a; Complement component C9b]
1_MSACR 6_ SFAVA 11_ ICILE 16_ ISILT 21_ AQYTT 26_ SYDPE 31_ LTESS 36_ GSASH 41_ IDCRM 46_ SPWSE 51_ WSQCD 56_ PCLRQ 61_ MFRSR 66_ SIEVF 71_ GQFNG 76_ KRCTD 81_ AVGDR 86_ RQCVP 91_ TEPCE 96_ DAEDD 101_ CGNDF 106_ QCSTG 111_ RCIKM 116_ RLRCN 121_ GDNDC 126_ GDFSD 131_ EDDCE 136_ SEPRP 141_ PCRDR 146_ VVEES 151_ ELART 156_ AGYGI 161_ NILGM 166_ DPLST 171_ PFDNE 176_ FYNGL 181_ CNRDR 186_ DGNTL 191_ TYYRR 196_ PWNVA 201_ SLIYE 206_ TKGEK 211_ NFRTE 216_ HYEEQ 221_ IEAFK 226_ SIIQE 231_ KTSNF 236_ NAAIS 241_ LKFTP 246_ TETNK 251_ AEQCC 256_ EETAS 261_ SISLH 266_ GKGSF 271_ RFSYS 276_ KNETY 281_ QLFLS 286_ YSSKK 291_ EKMFL 296_ HVKGE 301_ IHLGR 306_ FVMRN 311_ RDVVL 316_ TTTFV 321_ DDIKA 326_ LPTTY 331_ EKGEY 336_ FAFLE 341_ TYGTH 346_ YSSSG 351_ SLGGL 356_ YELIY 361_ VLDKA 366_ SMKRK 371_ GVELK 376_ DIKRC 381_ LGYHL 386_ DVSLA 391_ FSEIS 396_ VGAEF 401_ NKDDC 406_ VKRGE 411_ GRAVN 416_ ITSEN 421_ LIDDV 426_ VSLIR 431_ GGTRK 436_ YAFEL 441_ KEKLL 446_ RGTVI 451_ DVTDF 456_ VNWAS 461_ SINDA 466_ PVLIS 471_ QKLSP 476_ IYNLV 481_ PVKMK 486_ NAHLK 491_ KQNLE 496_ RAIED 501_ YINEF 506_ SVRKC 511_ HTCQN 516_ GGTVI 521_ LMDGK 526_ CLCAC 531_ PFKFE 536_ GIACE 541_ ISKQK 546_ ISEGL 551_PALEF
1: Pore-forming component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:22832194, PubMed:26841837, PubMed:26841934, PubMed:27052168, PubMed:30552328, PubMed:6177822, PubMed:9212048, PubMed:9634479). The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways (PubMed:9212048, PubMed:9634479). The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:9212048, PubMed:9634479). Constitutes the pore-forming subunit of the MAC complex: during MAC assembly, C9 associates with the C5b8 intermediate complex, and polymerizes to complete the pore (PubMed:26841934, PubMed:30111885, PubMed:30552328, PubMed:34752492, PubMed:4055801, PubMed:6177822)