Fibronectin (FN) (Cold-insoluble globulin) (CIG) [Cleaved into: Anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3]
1_MLRGP 6_ GPGLL 11_ LLAVQ 16_ CLGTA 21_ VPSTG 26_ ASKSK 31_ RQAQQ 36_ MVQPQ 41_ SPVAV 46_ SQSKP 51_ GCYDN 56_ GKHYQ 61_ INQQW 66_ ERTYL 71_ GNALV 76_ CTCYG 81_ GSRGF 86_ NCESK 91_ PEAEE 96_ TCFDK 101_ YTGNT 106_ YRVGD 111_ TYERP 116_ KDSMI 121_ WDCTC 126_ IGAGR 131_ GRISC 136_ TIANR 141_ CHEGG 146_ QSYKI 151_ GDTWR 156_ RPHET 161_ GGYML 166_ ECVCL 171_ GNGKG 176_ EWTCK 181_ PIAEK 186_ CFDHA 191_ AGTSY 196_ VVGET 201_ WEKPY 206_ QGWMM 211_ VDCTC 216_ LGEGS 221_ GRITC 226_ TSRNR 231_ CNDQD 236_ TRTSY 241_ RIGDT 246_ WSKKD 251_ NRGNL 256_ LQCIC 261_ TGNGR 266_ GEWKC 271_ ERHTS 276_ VQTTS 281_ SGSGP 286_ FTDVR 291_ AAVYQ 296_ PQPHP 301_ QPPPY 306_ GHCVT 311_ DSGVV 316_ YSVGM 321_ QWLKT 326_ QGNKQ 331_ MLCTC 336_ LGNGV 341_ SCQET 346_ AVTQT 351_ YGGNS 356_ NGEPC 361_ VLPFT 366_ YNGRT 371_ FYSCT 376_ TEGRQ 381_ DGHLW 386_ CSTTS 391_ NYEQD 396_ QKYSF 401_ CTDHT 406_ VLVQT 411_ RGGNS 416_ NGALC 421_ HFPFL 426_ YNNHN 431_ YTDCT 436_ SEGRR 441_ DNMKW 446_ CGTTQ 451_ NYDAD 456_ QKFGF 461_ CPMAA 466_ HEEIC 471_ TTNEG 476_ VMYRI 481_ GDQWD 486_ KQHDM 491_ GHMMR 496_ CTCVG 501_ NGRGE 506_ WTCIA 511_ YSQLR 516_ DQCIV 521_ DDITY 526_ NVNDT 531_ FHKRH 536_ EEGHM 541_ LNCTC 546_ FGQGR 551_ GRWKC 556_ DPVDQ 561_ CQDSE 566_ TGTFY 571_ QIGDS 576_ WEKYV 581_ HGVRY 586_ QCYCY 591_ GRGIG 596_ EWHCQ 601_ PLQTY 606_ PSSSG 611_ PVEVF 616_ ITETP 621_ SQPNS 626_ HPIQW 631_ NAPQP 636_ SHISK 641_ YILRW 646_ RPKNS 651_ VGRWK 656_ EATIP 661_ GHLNS 666_ YTIKG 671_ LKPGV 676_ VYEGQ 681_ LISIQ 686_ QYGHQ 691_ EVTRF 696_ DFTTT 701_ STSTP 706_ VTSNT 711_ VTGET 716_ TPFSP 721_ LVATS 726_ ESVTE 731_ ITASS 736_ FVVSW 741_ VSASD 746_ TVSGF 751_ RVEYE 756_ LSEEG 761_ DEPQY 766_ LDLPS 771_ TATSV 776_ NIPDL 781_ LPGRK 786_ YIVNV 791_ YQISE 796_ DGEQS 801_ LILST 806_ SQTTA 811_ PDAPP 816_ DTTVD 821_ QVDDT 826_ SIVVR 831_ WSRPQ 836_ APITG 841_ YRIVY 846_ SPSVE 851_ GSSTE 856_ LNLPE 861_ TANSV 866_ TLSDL 871_ QPGVQ 876_ YNITI 881_ YAVEE 886_ NQEST 891_ PVVIQ 896_ QETTG 901_ TPRSD 906_ TVPSP 911_ RDLQF 916_ VEVTD 921_ VKVTI 926_ MWTPP 931_ ESAVT 936_ GYRVD 941_ VIPVN 946_ LPGEH 951_ GQRLP 956_ ISRNT 961_ FAEVT 966_ GLSPG 971_ VTYYF 976_ KVFAV 981_ SHGRE 986_ SKPLT 991_ AQQTT 996_ KLDAP 1001_ TNLQF 1006_ VNETD 1011_ STVLV 1016_ RWTPP 1021_ RAQIT 1026_ GYRLT 1031_ VGLTR 1036_ RGQPR 1041_ QYNVG 1046_ PSVSK 1051_ YPLRN 1056_ LQPAS 1061_ EYTVS 1066_ LVAIK 1071_ GNQES 1076_ PKATG 1081_ VFTTL 1086_ QPGSS 1091_ IPPYN 1096_ TEVTE 1101_ TTIVI 1106_ TWTPA 1111_ PRIGF 1116_ KLGVR 1121_ PSQGG 1126_ EAPRE 1131_ VTSDS 1136_ GSIVV 1141_ SGLTP 1146_ GVEYV 1151_ YTIQV 1156_ LRDGQ 1161_ ERDAP 1166_ IVNKV 1171_ VTPLS 1176_ PPTNL 1181_ HLEAN 1186_ PDTGV 1191_ LTVSW 1196_ ERSTT 1201_ PDITG 1206_ YRITT 1211_ TPTNG 1216_ QQGNS 1221_ LEEVV 1226_ HADQS 1231_ SCTFD 1236_ NLSPG 1241_ LEYNV 1246_ SVYTV 1251_ KDDKE 1256_ SVPIS 1261_ DTIIP 1266_ EVPQL 1271_ TDLSF 1276_ VDITD 1281_ SSIGL 1286_ RWTPL 1291_ NSSTI 1296_ IGYRI 1301_ TVVAA 1306_ GEGIP 1311_ IFEDF 1316_ VDSSV 1321_ GYYTV 1326_ TGLEP 1331_ GIDYD 1336_ ISVIT 1341_ LINGG 1346_ ESAPT 1351_ TLTQQ 1356_ TAVPP 1361_ PTDLR 1366_ FTNIG 1371_ PDTMR 1376_ VTWAP 1381_ PPSID 1386_ LTNFL 1391_ VRYSP 1396_ VKNEE 1401_ DVAEL 1406_ SISPS 1411_ DNAVV 1416_ LTNLL 1421_ PGTEY 1426_ VVSVS 1431_ SVYEQ 1436_ HESTP 1441_ LRGRQ 1446_ KTGLD 1451_ SPTGI 1456_ DFSDI 1461_ TANSF 1466_ TVHWI 1471_ APRAT 1476_ ITGYR 1481_ IRHHP 1486_ EHFSG 1491_ RPRED 1496_ RVPHS 1501_ RNSIT 1506_ LTNLT 1511_ PGTEY 1516_ VVSIV 1521_ ALNGR 1526_ EESPL 1531_ LIGQQ 1536_ STVSD 1541_ VPRDL 1546_ EVVAA 1551_ TPTSL 1556_ LISWD 1561_ APAVT 1566_ VRYYR 1571_ ITYGE 1576_ TGGNS 1581_ PVQEF 1586_ TVPGS 1591_ KSTAT 1596_ ISGLK 1601_ PGVDY 1606_ TITVY 1611_ AVTGR 1616_ GDSPA 1621_ SSKPI 1626_ SINYR 1631_ TEIDK 1636_ PSQMQ 1641_ VTDVQ 1646_ DNSIS 1651_ VKWLP 1656_ SSSPV 1661_ TGYRV 1666_ TTTPK 1671_ NGPGP 1676_ TKTKT 1681_ AGPDQ 1686_ TEMTI 1691_ EGLQP 1696_ TVEYV 1701_ VSVYA 1706_ QNPSG 1711_ ESQPL 1716_ VQTAV 1721_ TNIDR 1726_ PKGLA 1731_ FTDVD 1736_ VDSIK 1741_ IAWES 1746_ PQGQV 1751_ SRYRV 1756_ TYSSP 1761_ EDGIH 1766_ ELFPA 1771_ PDGEE 1776_ DTAEL 1781_ QGLRP 1786_ GSEYT 1791_ VSVVA 1796_ LHDDM 1801_ ESQPL 1806_ IGTQS 1811_ TAIPA 1816_ PTDLK 1821_ FTQVT 1826_ PTSLS 1831_ AQWTP 1836_ PNVQL 1841_ TGYRV 1846_ RVTPK 1851_ EKTGP 1856_ MKEIN 1861_ LAPDS 1866_ SSVVV 1871_ SGLMV 1876_ ATKYE 1881_ VSVYA 1886_ LKDTL 1891_ TSRPA 1896_ QGVVT 1901_ TLENV 1906_ SPPRR 1911_ ARVTD 1916_ ATETT 1921_ ITISW 1926_ RTKTE 1931_ TITGF 1936_ QVDAV 1941_ PANGQ 1946_ TPIQR 1951_ TIKPD 1956_ VRSYT 1961_ ITGLQ 1966_ PGTDY 1971_ KIYLY 1976_ TLNDN 1981_ ARSSP 1986_ VVIDA 1991_ STAID 1996_ APSNL 2001_ RFLAT 2006_ TPNSL 2011_ LVSWQ 2016_ PPRAR 2021_ ITGYI 2026_ IKYEK 2031_ PGSPP 2036_ REVVP 2041_ RPRPG 2046_ VTEAT 2051_ ITGLE 2056_ PGTEY 2061_ TIYVI 2066_ ALKNN 2071_ QKSEP 2076_ LIGRK 2081_ KTDEL 2086_ PQLVT 2091_ LPHPN 2096_ LHGPE 2101_ ILDVP 2106_ STVQK 2111_ TPFVT 2116_ HPGYD 2121_ TGNGI 2126_ QLPGT 2131_ SGQQP 2136_ SVGQQ 2141_ MIFEE 2146_ HGFRR 2151_ TTPPT 2156_ TATPI 2161_ RHRPR 2166_ PYPPN 2171_ VGEEI 2176_ QIGHI 2181_ PREDV 2186_ DYHLY 2191_ PHGPG 2196_ LNPNA 2201_ STGQE 2206_ ALSQT 2211_ TISWA 2216_ PFQDT 2221_ SEYII 2226_ SCHPV 2231_ GTDEE 2236_ PLQFR 2241_ VPGTS 2246_ TSATL 2251_ TGLTR 2256_ GATYN 2261_ VIVEA 2266_ LKDQQ 2271_ RHKVR 2276_ EEVVT 2281_ VGNSV 2286_ NEGLN 2291_ QPTDD 2296_ SCFDP 2301_ YTVSH 2306_ YAVGD 2311_ EWERM 2316_ SESGF 2321_ KLLCQ 2326_ CLGFG 2331_ SGHFR 2336_ CDSSR 2341_ WCHDN 2346_ GVNYK 2351_ IGEKW 2356_ DRQGE 2361_ NGQMM 2366_ SCTCL 2371_ GNGKG 2376_ EFKCD 2381_ PHEAT 2386_ CYDDG 2391_ KTYHV 2396_ GEQWQ 2401_ KEYLG 2406_ AICSC 2411_ TCFGG 2416_ QRGWR 2421_ CDNCR 2426_ RPGGE 2431_ PSPEG 2436_ TTGQS 2441_ YNQYS 2446_ QRYHQ 2451_ RTNTN 2456_ VNCPI 2461_ ECFMP 2466_ LDVQA 2471_DREDS
1: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin (PubMed:3024962, PubMed:3593230, PubMed:3900070, PubMed:7989369). Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (PubMed:3024962, PubMed:3593230, PubMed:3900070, PubMed:7989369). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation (PubMed:34089617)
2: Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling
3: Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling