Ferritin heavy chain (Ferritin H subunit) (EC 1.16.3.1) (Cell proliferation-inducing gene 15 protein) [Cleaved into: Ferritin heavy chain, N-terminally processed]
1_MTTAS 6_ TSQVR 11_ QNYHQ 16_ DSEAA 21_ INRQI 26_ NLELY 31_ ASYVY 36_ LSMSY 41_ YFDRD 46_ DVALK 51_ NFAKY 56_ FLHQS 61_ HEERE 66_ HAEKL 71_ MKLQN 76_ QRGGR 81_ IFLQD 86_ IKKPD 91_ CDDWE 96_ SGLNA 101_ MECAL 106_ HLEKN 111_ VNQSL 116_ LELHK 121_ LATDK 126_ NDPHL 131_ CDFIE 136_ THYLN 141_ EQVKA 146_ IKELG 151_ DHVTN 156_ LRKMG 161_ APESG 166_ LAEYL 171_ FDKHT 176_LGDSD
1: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity (PubMed:9003196). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (PubMed:9003196). Also plays a role in delivery of iron to cells (By similarity). Mediates iron uptake in capsule cells of the developing kidney (By similarity). Delivery to lysosomes is mediated by the cargo receptor NCOA4 for autophagic degradation and release of iron (PubMed:24695223, PubMed:26436293)