ATP synthase protein 8 (A6L) (F-ATPase subunit 8)
1_MPQLN 6_ TTVWP 11_ TMITP 16_ MLLTL 21_ FLITQ 26_ LKMLN 31_ TNYHL 36_ PPSPK 41_ PMKMK 46_ NYNKP 51_ WEPKW 56_ TKICS 61_LHSLP
1: Subunit 8, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (PubMed:37244256)