Plasma kallikrein (EC 3.4.21.34) (Fletcher factor) (Kininogenin) (Plasma prekallikrein) (PKK) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain]
1_MILFK 6_ QATYF 11_ ISLFA 16_ TVSCG 21_ CLTQL 26_ YENAF 31_ FRGGD 36_ VASMY 41_ TPNAQ 46_ YCQMR 51_ CTFHP 56_ RCLLF 61_ SFLPA 66_ SSIND 71_ MEKRF 76_ GCFLK 81_ DSVTG 86_ TLPKV 91_ HRTGA 96_ VSGHS 101_ LKQCG 106_ HQISA 111_ CHRDI 116_ YKGVD 121_ MRGVN 126_ FNVSK 131_ VSSVE 136_ ECQKR 141_ CTNNI 146_ RCQFF 151_ SYATQ 156_ TFHKA 161_ EYRNN 166_ CLLKY 171_ SPGGT 176_ PTAIK 181_ VLSNV 186_ ESGFS 191_ LKPCA 196_ LSEIG 201_ CHMNI 206_ FQHLA 211_ FSDVD 216_ VARVL 221_ TPDAF 226_ VCRTI 231_ CTYHP 236_ NCLFF 241_ TFYTN 246_ VWKIE 251_ SQRNV 256_ CLLKT 261_ SESGT 266_ PSSST 271_ PQENT 276_ ISGYS 281_ LLTCK 286_ RTLPE 291_ PCHSK 296_ IYPGV 301_ DFGGE 306_ ELNVT 311_ FVKGV 316_ NVCQE 321_ TCTKM 326_ IRCQF 331_ FTYSL 336_ LPEDC 341_ KEEKC 346_ KCFLR 351_ LSMDG 356_ SPTRI 361_ AYGTQ 366_ GSSGY 371_ SLRLC 376_ NTGDN 381_ SVCTT 386_ KTSTR 391_ IVGGT 396_ NSSWG 401_ EWPWQ 406_ VSLQV 411_ KLTAQ 416_ RHLCG 421_ GSLIG 426_ HQWVL 431_ TAAHC 436_ FDGLP 441_ LQDVW 446_ RIYSG 451_ ILNLS 456_ DITKD 461_ TPFSQ 466_ IKEII 471_ IHQNY 476_ KVSEG 481_ NHDIA 486_ LIKLQ 491_ APLNY 496_ TEFQK 501_ PICLP 506_ SKGDT 511_ STIYT 516_ NCWVT 521_ GWGFS 526_ KEKGE 531_ IQNIL 536_ QKVNI 541_ PLVTN 546_ EECQK 551_ RYQDY 556_ KITQR 561_ MVCAG 566_ YKEGG 571_ KDACK 576_ GDSGG 581_ PLVCK 586_ HNGMW 591_ RLVGI 596_ TSWGE 601_ GCARR 606_ EQPGV 611_ YTKVA 616_ EYMDW 621_ ILEKT 626_ QSSDG 631_KAQMQ
1: Participates in the surface-dependent activation of blood coagulation. Activates, in a reciprocal reaction, coagulation factor XII/F12 after binding to negatively charged surfaces. Releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin