Interstitial collagenase (EC 3.4.24.7) (Fibroblast collagenase) (Matrix metalloproteinase-1) (MMP-1) [Cleaved into: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase]
1_MHSFP 6_ PLLLL 11_ LFWGV 16_ VSHSF 21_ PATLE 26_ TQEQD 31_ VDLVQ 36_ KYLEK 41_ YYNLK 46_ NDGRQ 51_ VEKRR 56_ NSGPV 61_ VEKLK 66_ QMQEF 71_ FGLKV 76_ TGKPD 81_ AETLK 86_ VMKQP 91_ RCGVP 96_ DVAQF 101_ VLTEG 106_ NPRWE 111_ QTHLT 116_ YRIEN 121_ YTPDL 126_ PRADV 131_ DHAIE 136_ KAFQL 141_ WSNVT 146_ PLTFT 151_ KVSEG 156_ QADIM 161_ ISFVR 166_ GDHRD 171_ NSPFD 176_ GPGGN 181_ LAHAF 186_ QPGPG 191_ IGGDA 196_ HFDED 201_ ERWTN 206_ NFREY 211_ NLHRV 216_ AAHEL 221_ GHSLG 226_ LSHST 231_ DIGAL 236_ MYPSY 241_ TFSGD 246_ VQLAQ 251_ DDIDG 256_ IQAIY 261_ GRSQN 266_ PVQPI 271_ GPQTP 276_ KACDS 281_ KLTFD 286_ AITTI 291_ RGEVM 296_ FFKDR 301_ FYMRT 306_ NPFYP 311_ EVELN 316_ FISVF 321_ WPQLP 326_ NGLEA 331_ AYEFA 336_ DRDEV 341_ RFFKG 346_ NKYWA 351_ VQGQN 356_ VLHGY 361_ PKDIY 366_ SSFGF 371_ PRTVK 376_ HIDAA 381_ LSEEN 386_ TGKTY 391_ FFVAN 396_ KYWRY 401_ DEYKR 406_ SMDPG 411_ YPKMI 416_ AHDFP 421_ GIGHK 426_ VDAVF 431_ MKDGF 436_ FYFFH 441_ GTRQY 446_ KFDPK 451_ TKRIL 456_ TLQKA 461_NSWFN
1: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (PubMed:1645757, PubMed:2153297, PubMed:2557822). In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity (PubMed:16807369)