Muellerian-inhibiting factor (Anti-Muellerian hormone) (AMH) (Muellerian-inhibiting substance) (MIS)
1_MRDLP 6_ LTSLA 11_ LVLSA 16_ LGALL 21_ GTEAL 26_ RAEEP 31_ AVGTS 36_ GLIFR 41_ EDLDW 46_ PPGSP 51_ QEPLC 56_ LVALG 61_ GDSNG 66_ SSSPL 71_ RVVGA 76_ LSAYE 81_ QAFLG 86_ AVQRA 91_ RWGPR 96_ DLATF 101_ GVCNT 106_ GDRQA 111_ ALPSL 116_ RRLGA 121_ WLRDP 126_ GGQRL 131_ VVLHL 136_ EEVTW 141_ EPTPS 146_ LRFQE 151_ PPPGG 156_ AGPPE 161_ LALLV 166_ LYPGP 171_ GPEVT 176_ VTRAG 181_ LPGAQ 186_ SLCPS 191_ RDTRY 196_ LVLAV 201_ DRPAG 206_ AWRGS 211_ GLALT 216_ LQPRG 221_ EDSRL 226_ STARL 231_ QALLF 236_ GDDHR 241_ CFTRM 246_ TPALL 251_ LLPRS 256_ EPAPL 261_ PAHGQ 266_ LDTVP 271_ FPPPR 276_ PSAEL 281_ EESPP 286_ SADPF 291_ LETLT 296_ RLVRA 301_ LRVPP 306_ ARASA 311_ PRLAL 316_ DPDAL 321_ AGFPQ 326_ GLVNL 331_ SDPAA 336_ LERLL 341_ DGEEP 346_ LLLLL 351_ RPTAA 356_ TTGDP 361_ APLHD 366_ PTSAP 371_ WATAL 376_ ARRVA 381_ AELQA 386_ AAAEL 391_ RSLPG 396_ LPPAT 401_ APLLA 406_ RLLAL 411_ CPGGP 416_ GGLGD 421_ PLRAL 426_ LLLKA 431_ LQGLR 436_ VEWRG 441_ RDPRG 446_ PGRAQ 451_ RSAGA 456_ TAADG 461_ PCALR 466_ ELSVD 471_ LRAER 476_ SVLIP 481_ ETYQA 486_ NNCQG 491_ VCGWP 496_ QSDRN 501_ PRYGN 506_ HVVLL 511_ LKMQV 516_ RGAAL 521_ ARPPC 526_ CVPTA 531_ YAGKL 536_ LISLS 541_ EERIS 546_ AHHVP 551_NMVAT
1: Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation (PubMed:34155118, PubMed:3754790, PubMed:8469238). Also plays a role in Leydig cell differentiation and function (By similarity). In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles (PubMed:14742691). AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression (PubMed:20861221, PubMed:34155118)