Antileukoproteinase (ALP) (BLPI) (HUSI-1) (Mucus proteinase inhibitor) (MPI) (Protease inhibitor WAP4) (Secretory leukocyte protease inhibitor) (Seminal proteinase inhibitor) (WAP four-disulfide core domain protein 4)
1_MKSSG 6_ LFPFL 11_ VLLAL 16_ GTLAP 21_ WAVEG 26_ SGKSF 31_ KAGVC 36_ PPKKS 41_ AQCLR 46_ YKKPE 51_ CQSDW 56_ QCPGK 61_ KRCCP 66_ DTCGI 71_ KCLDP 76_ VDTPN 81_ PTRRK 86_ PGKCP 91_ VTYGQ 96_ CLMLN 101_ PPNFC 106_ EMDGQ 111_ CKRDL 116_ KCCMG 121_ MCGKS 126_CVSPV
1: Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G (PubMed:10702419, PubMed:2039600, PubMed:2110563, PubMed:24121345, PubMed:3462719, PubMed:3533531). Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses (PubMed:10702419, PubMed:24352879). Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to infection by L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (By similarity). Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells (PubMed:24352879)