3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34)
1_MLSRL 6_ FRMHG 11_ LFVAS 16_ HPWEV 21_ IVGTV 26_ TLTIC 31_ MMSMN 36_ MFTGN 41_ NKICG 46_ WNYEC 51_ PKFEE 56_ DVLSS 61_ DIIIL 66_ TITRC 71_ IAILY 76_ IYFQF 81_ QNLRQ 86_ LGSKY 91_ ILGIA 96_ GLFTI 101_ FSSFV 106_ FSTVV 111_ IHFLD 116_ KELTG 121_ LNEAL 126_ PFFLL 131_ LIDLS 136_ RASTL 141_ AKFAL 146_ SSNSQ 151_ DEVRE 156_ NIARG 161_ MAILG 166_ PTFTL 171_ DALVE 176_ CLVIG 181_ VGTMS 186_ GVRQL 191_ EIMCC 196_ FGCMS 201_ VLANY 206_ FVFMT 211_ FFPAC 216_ VSLVL 221_ ELSRE 226_ SREGR 231_ PIWQL 236_ SHFAR 241_ VLEEE 246_ ENKPN 251_ PVTQR 256_ VKMIM 261_ SLGLV 266_ LVHAH 271_ SRWIA 276_ DPSPQ 281_ NSTAD 286_ TSKVS 291_ LGLDE 296_ NVSKR 301_ IEPSV 306_ SLWQF 311_ YLSKM 316_ ISMDI 321_ EQVIT 326_ LSLAL 331_ LLAVK 336_ YIFFE 341_ QTETE 346_ STLSL 351_ KNPIT 356_ SPVVT 361_ QKKVP 366_ DNCCR 371_ REPML 376_ VRNNQ 381_ KCDSV 386_ EEETG 391_ INRER 396_ KVEVI 401_ KPLVA 406_ ETDTP 411_ NRATF 416_ VVGNS 421_ SLLDT 426_ SSVLV 431_ TQEPE 436_ IELPR 441_ EPRPN 446_ EECLQ 451_ ILGNA 456_ EKGAK 461_ FLSDA 466_ EIIQL 471_ VNAKH 476_ IPAYK 481_ LETLM 486_ ETHER 491_ GVSIR 496_ RQLLS 501_ KKLSE 506_ PSSLQ 511_ YLPYR 516_ DYNYS 521_ LVMGA 526_ CCENV 531_ IGYMP 536_ IPVGV 541_ AGPLC 546_ LDEKE 551_ FQVPM 556_ ATTEG 561_ CLVAS 566_ TNRGC 571_ RAIGL 576_ GGGAS 581_ SRVLA 586_ DGMTR 591_ GPVVR 596_ LPRAC 601_ DSAEV 606_ KAWLE 611_ TSEGF 616_ AVIKE 621_ AFDST 626_ SRFAR 631_ LQKLH 636_ TSIAG 641_ RNLYI 646_ RFQSR 651_ SGDAM 656_ GMNMI 661_ SKGTE 666_ KALSK 671_ LHEYF 676_ PEMQI 681_ LAVSG 686_ NYCTD 691_ KKPAA 696_ INWIE 701_ GRGKS 706_ VVCEA 711_ VIPAK 716_ VVREV 721_ LKTTT 726_ EAMIE 731_ VNINK 736_ NLVGS 741_ AMAGS 746_ IGGYN 751_ AHAAN 756_ IVTAI 761_ YIACG 766_ QDAAQ 771_ NVGSS 776_ NCITL 781_ MEASG 786_ PTNED 791_ LYISC 796_ TMPSI 801_ EIGTV 806_ GGGTN 811_ LLPQQ 816_ ACLQM 821_ LGVQG 826_ ACKDN 831_ PGENA 836_ RQLAR 841_ IVCGT 846_ VMAGE 851_ LSLMA 856_ ALAAG 861_ HLVKS 866_ HMIHN 871_ RSKIN 876_ LQDLQ 881_GACTK
1: Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis (PubMed:21357570, PubMed:2991281, PubMed:36745799, PubMed:6995544). HMGCR is the main target of statins, a class of cholesterol-lowering drugs (PubMed:11349148, PubMed:18540668, PubMed:36745799)