Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35) [Cleaved into: Annexin Ac2-26]
1_MAMVS 6_ EFLKQ 11_ AWFIE 16_ NEEQE 21_ YVQTV 26_ KSSKG 31_ GPGSA 36_ VSPYP 41_ TFNPS 46_ SDVAA 51_ LHKAI 56_ MVKGV 61_ DEATI 66_ IDILT 71_ KRNNA 76_ QRQQI 81_ KAAYL 86_ QETGK 91_ PLDET 96_ LKKAL 101_ TGHLE 106_ EVVLA 111_ LLKTP 116_ AQFDA 121_ DELRA 126_ AMKGL 131_ GTDED 136_ TLIEI 141_ LASRT 146_ NKEIR 151_ DINRV 156_ YREEL 161_ KRDLA 166_ KDITS 171_ DTSGD 176_ FRNAL 181_ LSLAK 186_ GDRSE 191_ DFGVN 196_ EDLAD 201_ SDARA 206_ LYEAG 211_ ERRKG 216_ TDVNV 221_ FNTIL 226_ TTRSY 231_ PQLRR 236_ VFQKY 241_ TKYSK 246_ HDMNK 251_ VLDLE 256_ LKGDI 261_ EKCLT 266_ AIVKC 271_ ATSKP 276_ AFFAE 281_ KLHQA 286_ MKGVG 291_ TRHKA 296_ LIRIM 301_ VSRSE 306_ IDMND 311_ IKAFY 316_ QKMYG 321_ ISLCQ 326_ AILDE 331_ TKGDY 336_ EKILV 341_ALCGG
1: Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity)
2: Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591)