Platelet-derived growth factor subunit A (PDGF subunit A) (PDGF-1) (Platelet-derived growth factor A chain) (Platelet-derived growth factor alpha polypeptide)
1_MRTLA 6_ CLLLL 11_ GCGYL 16_ AHVLA 21_ EEAEI 26_ PREVI 31_ ERLAR 36_ SQIHS 41_ IRDLQ 46_ RLLEI 51_ DSVGS 56_ EDSLD 61_ TSLRA 66_ HGVHA 71_ TKHVP 76_ EKRPL 81_ PIRRK 86_ RSIEE 91_ AVPAV 96_ CKTRT 101_ VIYEI 106_ PRSQV 111_ DPTSA 116_ NFLIW 121_ PPCVE 126_ VKRCT 131_ GCCNT 136_ SSVKC 141_ QPSRV 146_ HHRSV 151_ KVAKV 156_ EYVRK 161_ KPKLK 166_ EVQVR 171_ LEEHL 176_ ECACA 181_ TTSLN 186_ PDYRE 191_ EDTGR 196_ PRESG 201_ KKRKR 206_KRLKP
1: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity)