Major prion protein (PrP) (ASCR) (PrP27-30) (PrP33-35C) (CD antigen CD230)
1_MANLG 6_ CWMLV 11_ LFVAT 16_ WSDLG 21_ LCKKR 26_ PKPGG 31_ WNTGG 36_ SRYPG 41_ QGSPG 46_ GNRYP 51_ PQGGG 56_ GWGQP 61_ HGGGW 66_ GQPHG 71_ GGWGQ 76_ PHGGG 81_ WGQPH 86_ GGGWG 91_ QGGGT 96_ HSQWN 101_ KPSKP 106_ KTNMK 111_ HMAGA 116_ AAAGA 121_ VVGGL 126_ GGYML 131_ GSAMS 136_ RPIIH 141_ FGSDY 146_ EDRYY 151_ RENMH 156_ RYPNQ 161_ VYYRP 166_ MDEYS 171_ NQNNF 176_ VHDCV 181_ NITIK 186_ QHTVT 191_ TTTKG 196_ ENFTE 201_ TDVKM 206_ MERVV 211_ EQMCI 216_ TQYER 221_ ESQAY 226_ YQRGS 231_ SMVLF 236_ SSPPV 241_ ILLIS 246_FLIFL
1: Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity)