Phosphatidylcholine-sterol acyltransferase (EC 2.3.1.43) (1-alkyl-2-acetylglycerophosphocholine esterase) (EC 3.1.1.47) (Lecithin-cholesterol acyltransferase) (Phospholipid-cholesterol acyltransferase) (Platelet-activating factor acetylhydrolase) (PAF acetylhydrolase)
1_MGPPG 6_ SPWQW 11_ VTLLL 16_ GLLLP 21_ PAAPF 26_ WLLNV 31_ LFPPH 36_ TTPKA 41_ ELSNH 46_ TRPVI 51_ LVPGC 56_ LGNQL 61_ EAKLD 66_ KPDVV 71_ NWMCY 76_ RKTED 81_ FFTIW 86_ LDLNM 91_ FLPLG 96_ VDCWI 101_ DNTRV 106_ VYNRS 111_ SGLVS 116_ NAPGV 121_ QIRVP 126_ GFGKT 131_ YSVEY 136_ LDSSK 141_ LAGYL 146_ HTLVQ 151_ NLVNN 156_ GYVRD 161_ ETVRA 166_ APYDW 171_ RLEPG 176_ QQEEY 181_ YRKLA 186_ GLVEE 191_ MHAAY 196_ GKPVF 201_ LIGHS 206_ LGCLH 211_ LLYFL 216_ LRQPQ 221_ AWKDR 226_ FIDGF 231_ ISLGA 236_ PWGGS 241_ IKPML 246_ VLASG 251_ DNQGI 256_ PIMSS 261_ IKLKE 266_ EQRIT 271_ TTSPW 276_ MFPSR 281_ MAWPE 286_ DHVFI 291_ STPSF 296_ NYTGR 301_ DFQRF 306_ FADLH 311_ FEEGW 316_ YMWLQ 321_ SRDLL 326_ AGLPA 331_ PGVEV 336_ YCLYG 341_ VGLPT 346_ PRTYI 351_ YDHGF 356_ PYTDP 361_ VGVLY 366_ EDGDD 371_ TVATR 376_ STELC 381_ GLWQG 386_ RQPQP 391_ VHLLP 396_ LHGIQ 401_ HLNMV 406_ FSNLT 411_ LEHIN 416_ AILLG 421_ AYRQG 426_ PPASP 431_TASPE
1: Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs) (PubMed:10329423, PubMed:19065001, PubMed:26195816). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107). Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (PubMed:10722751). Catalyzes the hydrolysis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor or PAF) to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (PubMed:8016111). Also catalyzes the transfer of the acetate group from PAF to 1-hexadecanoyl-sn-glycero-3-phosphocholine forming lyso-PAF (PubMed:8016111). Catalyzes the esterification of (24S)-hydroxycholesterol (24(S)OH-C), also known as cerebrosterol to produce 24(S)OH-C monoesters (PubMed:24620755)