Thymidine kinase, cytosolic (EC 2.7.1.21)
1_MSCIN 6_ LPTVL 11_ PGSPS 16_ KTRGQ 21_ IQVIL 26_ GPMFS 31_ GKSTE 36_ LMRRV 41_ RRFQI 46_ AQYKC 51_ LVIKY 56_ AKDTR 61_ YSSSF 66_ CTHDR 71_ NTMEA 76_ LPACL 81_ LRDVA 86_ QEALG 91_ VAVIG 96_ IDEGQ 101_ FFPDI 106_ VEFCE 111_ AMANA 116_ GKTVI 121_ VAALD 126_ GTFQR 131_ KPFGA 136_ ILNLV 141_ PLAES 146_ VVKLT 151_ AVCME 156_ CFREA 161_ AYTKR 166_ LGTEK 171_ EVEVI 176_ GGADK 181_ YHSVC 186_ RLCYF 191_ KKASG 196_ QPAGP 201_ DNKEN 206_ CPVPG 211_ KPGEA 216_ VAARK 221_ LFAPQ 226_QILQC
1: Cell-cycle-regulated enzyme of importance in nucleotide metabolism (PubMed:9575153). Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate (PubMed:22385435). Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration (Probable). Also important for the activation of anticancer and antiviral nucleoside analog prodrugs such as 1-b-d-arabinofuranosylcytosine (AraC) and 3c-azido-3c-deoxythymidine (AZT) (PubMed:22385435)