Histidine-rich glycoprotein (Histidine-proline-rich glycoprotein) (HPRG)
1_MKALI 6_ AALLL 11_ ITLQY 16_ SCAVS 21_ PTDCS 26_ AVEPE 31_ AEKAL 36_ DLINK 41_ RRRDG 46_ YLFQL 51_ LRIAD 56_ AHLDR 61_ VENTT 66_ VYYLV 71_ LDVQE 76_ SDCSV 81_ LSRKY 86_ WNDCE 91_ PPDSR 96_ RPSEI 101_ VIGQC 106_ KVIAT 111_ RHSHE 116_ SQDLR 121_ VIDFN 126_ CTTSS 131_ VSSAL 136_ ANTKD 141_ SPVLI 146_ DFFED 151_ TERYR 156_ KQANK 161_ ALEKY 166_ KEEND 171_ DFASF 176_ RVDRI 181_ ERVAR 186_ VRGGE 191_ GTGYF 196_ VDFSV 201_ RNCPR 206_ HHFPR 211_ HPNVF 216_ GFCRA 221_ DLFYD 226_ VEALD 231_ LESPK 236_ NLVIN 241_ CEVFD 246_ PQEHE 251_ NINGV 256_ PPHLG 261_ HPFHW 266_ GGHER 271_ SSTTK 276_ PPFKP 281_ HGSRD 286_ HHHPH 291_ KPHEH 296_ GPPPP 301_ PDERD 306_ HSHGP 311_ PLPQG 316_ PPPLL 321_ PMSCS 326_ SCQHA 331_ TFGTN 336_ GAQRH 341_ SHNNN 346_ SSDLH 351_ PHKHH 356_ SHEQH 361_ PHGHH 366_ PHAHH 371_ PHEHD 376_ THRQH 381_ PHGHH 386_ PHGHH 391_ PHGHH 396_ PHGHH 401_ PHGHH 406_ PHCHD 411_ FQDYG 416_ PCDPP 421_ PHNQG 426_ HCCHG 431_ HGPPP 436_ GHLRR 441_ RGPGK 446_ GPRPF 451_ HCRQI 456_ GSVYR 461_ LPPLR 466_ KGEVL 471_ PLPEA 476_ NFPSF 481_ PLPHH 486_ KHPLK 491_ PDNQP 496_ FPQSV 501_ SESCP 506_ GKFKS 511_ GFPQV 516_SMFFT
1: Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2. Acts as a regulator of the vascular endothelial growth factor (VEGF) signaling pathway; inhibits endothelial cell motility by reducing VEGF-induced complex formation between PXN/paxillin and ILK/integrin-linked protein kinase and by promoting inhibition of VEGF-induced tyrosine phosphorylation of focal adhesion kinases and alpha-actinins in endothelial cells. Also plays a role in the regulation of tumor angiogenesis and tumor immune surveillance. Normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis