Argininosuccinate lyase (ASAL) (EC 4.3.2.1) (Arginosuccinase)
1_MASES 6_ GKLWG 11_ GRFVG 16_ AVDPI 21_ MEKFN 26_ ASIAY 31_ DRHLW 36_ EVDVQ 41_ GSKAY 46_ SRGLE 51_ KAGLL 56_ TKAEM 61_ DQILH 66_ GLDKV 71_ AEEWA 76_ QGTFK 81_ LNSND 86_ EDIHT 91_ ANERR 96_ LKELI 101_ GATAG 106_ KLHTG 111_ RSRND 116_ QVVTD 121_ LRLWM 126_ RQTCS 131_ TLSGL 136_ LWELI 141_ RTMVD 146_ RAEAE 151_ RDVLF 156_ PGYTH 161_ LQRAQ 166_ PIRWS 171_ HWILS 176_ HAVAL 181_ TRDSE 186_ RLLEV 191_ RKRIN 196_ VLPLG 201_ SGAIA 206_ GNPLG 211_ VDREL 216_ LRAEL 221_ NFGAI 226_ TLNSM 231_ DATSE 236_ RDFVA 241_ EFLFW 246_ ASLCM 251_ THLSR 256_ MAEDL 261_ ILYCT 266_ KEFSF 271_ VQLSD 276_ AYSTG 281_ SSLMP 286_ QKKNP 291_ DSLEL 296_ IRSKA 301_ GRVFG 306_ RCAGL 311_ LMTLK 316_ GLPST 321_ YNKDL 326_ QEDKE 331_ AVFEV 336_ SDTMS 341_ AVLQV 346_ ATGVI 351_ STLQI 356_ HQENM 361_ GQALS 366_ PDMLA 371_ TDLAY 376_ YLVRK 381_ GMPFR 386_ QAHEA 391_ SGKAV 396_ FMAET 401_ KGVAL 406_ NQLSL 411_ QELQT 416_ ISPLF 421_ SGDVI 426_ CVWDY 431_ GHSVE 436_ QYGAL 441_ GGTAR 446_ SSVDW 451_ QIRQV 456_RALLQ
1: Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in nonhepatic tissues (PubMed:11747432, PubMed:11747433, PubMed:22081021, PubMed:2263616, PubMed:9045711). Essential regulator of intracellular and extracellular L-arginine pools. As part of citrulline-nitric oxide cycle, forms tissue-specific multiprotein complexes with argininosuccinate synthase ASS1, transport protein SLC7A1 and nitric oxide synthase NOS1, NOS2 or NOS3, allowing for cell-autonomous L-arginine synthesis while channeling extracellular L-arginine to nitric oxide synthesis pathway (PubMed:22081021)